التفاصيل البيبلوغرافية
| العنوان: |
Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project |
| المؤلفون: |
Alosco, Michael L., Mariani, Megan L., Adler, Charles H., Balcer, Laura J., Bernick, Charles, Au, Rhoda, Banks, Sarah J., Barr, William B., Bouix, Sylvain, Cantu, Robert C., Coleman, Michael J., Dodick, David W., Farrer, Lindsay A., Geda, Yonas E., Katz, Douglas I., Koerte, Inga K., Kowall, Neil W., Lin, Alexander P., Marcus, Daniel S., Marek, Kenneth L., McClean, Michael D., McKee, Ann C., Mez, Jesse, Palmisano, Joseph N., Peskind, Elaine R., Tripodis, Yorghos, Turner, Robert W., Wethe, Jennifer V., Cummings, Jeffrey L., Reiman, Eric M., Shenton, Martha E., Stern, Robert A., Balcer, Laura, Banks, Sarah, Barr, William, Chen, Kewei, Farrer, Lindsay, Fitzsimmons, Jennifer, Geda, Yonas, Goldberg, Judith, Helm, Robert |
| المساهمون: |
National Institute of Neurological Disorders and Stroke |
| المصدر: |
Alzheimer's Research & Therapy ; volume 13, issue 1 ; ISSN 1758-9193 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Cognitive Neuroscience, Neurology (clinical), Neurology |
| الوصف: |
Background Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, and rugby players. CTE cannot yet be diagnosed during life. In December 2015, the National Institute of Neurological Disorders and Stroke awarded a seven-year grant (U01NS093334) to fund the “Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project.” The objectives of this multicenter project are to: develop in vivo fluid and neuroimaging biomarkers for CTE; characterize its clinical presentation; refine and validate clinical research diagnostic criteria (i.e., traumatic encephalopathy syndrome [TES]); examine repetitive head impact exposure, genetic, and other risk factors; and provide shared resources of anonymized data and biological samples to the research community. In this paper, we provide a detailed overview of the rationale, design, and methods for the DIAGNOSE CTE Research Project. Methods The targeted sample and sample size was 240 male participants, ages 45–74, including 120 former professional football players, 60 former collegiate football players, and 60 asymptomatic participants without a history of head trauma or participation in organized contact sports. Participants were evaluated at one of four U.S. sites and underwent the following baseline procedures: neurological and neuropsychological examinations; tau and amyloid positron emission tomography; magnetic resonance imaging and spectroscopy; lumbar puncture; blood and saliva collection; and standardized self-report measures of neuropsychiatric, cognitive, and daily functioning. Study partners completed similar informant-report measures. Follow-up evaluations were intended to be in-person and at 3 years post-baseline. Multidisciplinary diagnostic consensus conferences are held, and the reliability and validity ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s13195-021-00872-x |
| DOI: |
10.1186/s13195-021-00872-x.pdf |
| DOI: |
10.1186/s13195-021-00872-x/fulltext.html |
| الإتاحة: |
https://doi.org/10.1186/s13195-021-00872-xTest |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.5023F608 |
| قاعدة البيانات: |
BASE |
