دورية أكاديمية
TNAP as a therapeutic target for cardiovascular calcification - a discussion of its pleiotropic functions in the body
| العنوان: | TNAP as a therapeutic target for cardiovascular calcification - a discussion of its pleiotropic functions in the body |
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| المؤلفون: | Goettsch, C., Strzelecka-Kiliszek, A., Bessueille, L., Quillard, T., Mechtouff, L., Pikula, S., Canet-Soulas, E., Millán, J. L., Fonta, Caroline, Magne, D. |
| المساهمون: | Universitätsklinikum RWTH Aachen - University Hospital Aachen Aachen, Germany (UKA), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Nencki Institute of Experimental Biology, Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences (PAN), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Sarcomes osseux et remodelage des tissus calcifiés - INSERM U1238 (Phy-Os), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Hospices Civils de Lyon (HCL), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sanford Burnham Prebys Medical Discovery Institute, Centre de recherche cerveau et cognition (CERCO UMR5549), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT) |
| المصدر: | ISSN: 0008-6363 ; Cardiovascular Research ; https://inserm.hal.science/inserm-03261168Test ; Cardiovascular Research, 2022, 118 (1), pp.84-96. ⟨10.1093/cvr/cvaa299⟩. |
| بيانات النشر: | HAL CCSD Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Tissue non-specific alkaline phosphatase, Cardiovascular calcification, Therapeutic target, Inhibition, Inflammation, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Cardiovascular calcification (CVC) is associated with increased morbidity and mortality. It develops in several diseases and locations, such as in the tunica intima in atherosclerosis plaques, in the tunica media in type 2 diabetes and chronic kidney disease, and in aortic valves. In spite of the wide occurrence of CVC and its detrimental effects on cardiovascular diseases (CVD), no treatment is yet available. Most of CVC involve mechanisms similar to those occurring during endochondral and/or intramembranous ossification. Logically, since tissue-nonspecific alkaline phosphatase (TNAP) is the key-enzyme responsible for skeletal/dental mineralization, it is a promising target to limit CVC. Tools have recently been developed to inhibit its activity and preclinical studies conducted in animal models of vascular calcification already provided promising results. Nevertheless, as its name indicates, TNAP is ubiquitous and recent data indicate that it dephosphorylates different substrates in vivo to participate in other important physiological functions besides mineralization. For instance, TNAP is involved in the metabolism of pyridoxal phosphate and the production of neurotransmitters. TNAP has also been described as an anti-inflammatory enzyme able to dephosphorylate adenosine nucleotides and lipopolysaccharide. A better understanding of the full spectrum of TNAP's functions is needed to better characterize the effects of TNAP inhibition in diseases associated with CVC. In this review, after a brief description of the different types of CVC, we describe the newly uncovered additional functions of TNAP and discuss the expected consequences of its systemic inhibition in vivo. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33070177; inserm-03261168; https://inserm.hal.science/inserm-03261168Test; https://inserm.hal.science/inserm-03261168/documentTest; https://inserm.hal.science/inserm-03261168/file/cvaa299.pdfTest; PUBMED: 33070177; WOS: 000743142600017 |
| DOI: | 10.1093/cvr/cvaa299 |
| الإتاحة: | https://doi.org/10.1093/cvr/cvaa299Test https://inserm.hal.science/inserm-03261168Test https://inserm.hal.science/inserm-03261168/documentTest https://inserm.hal.science/inserm-03261168/file/cvaa299.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.4FFFCB65 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cvr/cvaa299 |
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