دورية أكاديمية
High Hydrostatic Pressure Processing of Human Milk Increases Apelin and GLP-1 Contents to Modulate Gut Contraction and Glucose Metabolism in Mice Compared to Holder Pasteurization.
| العنوان: | High Hydrostatic Pressure Processing of Human Milk Increases Apelin and GLP-1 Contents to Modulate Gut Contraction and Glucose Metabolism in Mice Compared to Holder Pasteurization. |
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| المؤلفون: | Wemelle, Eve, Marousez, Lucie, De Lamballerie, Marie, Knauf, Claude, Lesage, Jean |
| المساهمون: | Université de Lille, Inserm, CHU Lille, NeuroMicrobiota, Institut de Recherche en Santé Digestive IRSD, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, Laboratoire de génie des procédés - environnement - agroalimentaire GEPEA, École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique ONIRIS, 515762|||NeuroMicrobiota (VALID) |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | human milk, high hydrostatic pressure, holder pasteurization, GLP-1, apelin, glucose metabolism |
| الوصف: | Background: High hydrostatic pressure (HHP) processing is a non-thermal method proposed as an alternative to Holder pasteurization (HoP) for the sterilization of human breast milk (BM). HHP preserves numerous milk bioactive factors that are degraded by HoP, but no data are available for milk apelin and glucagon-like peptide 1 (GLP-1), two hormones implicated in the control of glucose metabolism directly and via the gut–brain axis. This study aims to determine the effects of HoP and HHP processing on apelin and GLP-1 concentrations in BM and to test the effect of oral treatments with HoP- and HHP-BM on intestinal contractions and glucose metabolism in adult mice. Methods: Mice were treated by daily oral gavages with HoP- or HHP-BM during one week before intestinal contractions, and glucose tolerance was assessed. mRNA expression of enteric neuronal enzymes known to control intestinal contraction was measured. Results: HoP-BM displayed a reduced concentration of apelin and GLP-1, whereas HHP processing preserved these hormones close to their initial levels in raw milk. Chronic HHP-BM administration to mice increased ileal mRNA nNos expression level leading to a decrease in gut contraction associated with improved glucose tolerance. Conclusion: In comparison to HoP, HPP processing of BM preserves both apelin and GLP-1 and improves glucose tolerance by acting on gut contractions. This study reinforces previous findings demonstrating that HHP processing provides BM with a higher biological value than BM treated by HoP. ; 14 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/rdf+xml; charset=utf-8; application/pdf |
| اللغة: | English |
| العلاقة: | Nutrients; http://hdl.handle.net/20.500.12210/100953Test |
| الإتاحة: | https://doi.org/20.500.12210/100953Test https://hdl.handle.net/20.500.12210/100953Test |
| حقوق: | Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4FFBB417 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |