دورية أكاديمية
Immunomodulatory activity of argentatins A and B isolated from guayule
| العنوان: | Immunomodulatory activity of argentatins A and B isolated from guayule |
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| المؤلفون: | Silva-Nolasco, Aniela M., Cruz-Morcillo, Miguel A. de la, García-Martínez, M. Mercedes, Zalacain, Amaya, González Gálvez, Beatriz, Carmona, Manuel |
| المساهمون: | Nisha Singh |
| سنة النشر: | 2024 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 577.1, 577.2, Biología molecular (Farmacia), Bioquímica (Farmacia), 32 Ciencias Médicas |
| الوصف: | Argentatins are secondary metabolites synthesized by guayule with numerous potential medical applications. In addition to inhibiting insect growth, they are endowed with several pharmacological properties including antimicrobial and antitumorigenic activity. However, their potential as immunomodulators remains unexplored. The aim of the present study was to investigate whether argentatins can modulate the function of the immune system. Human mesenchymal stem cells were treated with argentatins and the production of several anti- and proinflammatory cytokines was evaluated. The effect of argentatins on the polarization of CD4+ T-lymphocytes and macrophages was also assessed. Results demonstrated that argentatins can modulate the production of proinflammatory cytokines and the polarization of cellular phenotypes, including Th2 lymphocytes and M1 macrophages. These findings suggest that argentatins are promising therapeutic agents in autoimmune or allergic diseases, and open new perspectives for the investigation of argentatins in immune response and in the development of more targeted and effective immunomodulatory therapies. ; Ministerio de Ciencia, Innovación y Universidades ; European Commission-ERC ; Universidad de Castilla-La Mancha ; Depto. de Bioquímica y Biología Molecular ; Fac. de Farmacia ; TRUE ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | info:eu-repo/grantAgreement/AEI/Plan estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-1424550B-100; https://hdl.handle.net/20.500.14352/104737Test |
| DOI: | 10.1371/journal.pone.0304713 |
| الإتاحة: | https://doi.org/20.500.14352/10473710.1371/journal.pone.0304713Test https://hdl.handle.net/20.500.14352/104737Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.4FBF4FE4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0304713 |