دورية أكاديمية
Autoimmunity and hepatitis a vaccine in children
| العنوان: | Autoimmunity and hepatitis a vaccine in children |
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| المساهمون: | Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilimdalı., orcid:0000-0003-0463-6818, orcid:0000-0003-0710-5422, orcid:0000-0002-9416-1512, orcid:0000-0001-8571-2581, Karalı, Zuhal, Tanır, Sevgen Başaranoğlu, Karalı, Yasin, Oral, Haluk Barbaros, Kılıç, Sara Şebnem, AAH-1658-2021, K-7285-2012, C-7392-2019, U-2921-2017, 35791967200, 53868381900, 49863694000, 7004498001, 34975059200 |
| بيانات النشر: | Esmon Publicidad |
| سنة النشر: | 2011 |
| المجموعة: | Açık Erişim@BUU (Bursa Uludağ Üniversitesi) |
| مصطلحات موضوعية: | Allergy, Immunology, Hepatitis A vaccine, Autoimmunity, ANA, Anti-cardiolipin antibody, Guillain-barre-syndrome, B-Vaccine, Antibodies, Risk, Adolescent, Antibody formation, Autoantibodies, Autoantigens, Child, preschool, Female, Follow-up studies, Hepatitis a vaccines, Humans, Male, Turkey, Vaccination, Pneumococcal Vaccines, Macrophagic Myofasciitis, Antinuclear antibody, Cardiolipin antibody, DNA antibody, Double stranded DNA antibody, Immunoglobulin G antibody |
| الوصف: | Background: Universal vaccination remains the most effective way of preventing the spread of many infectious diseases. Although most adverse effects attributed to vaccines are mild, rare reactions such as autoimmunity do occur. Objectives: We aimed to evaluate the possible role played by hepatitis A vaccine (HAV) in inducing the synthesis of autoantibodies. The study included 40 healthy children vaccinated with 2 doses of HAV at a 6-month interval. The children were investigated for autoantibodies including anti-nuclear antibodies (ANAs), anti smooth muscle antibodies, anti-nDNA, anti-microsomal antibodies, anti-cardiolipin (aCL) immunoglobulin (Ig) M/IgG, anti-ds DNA, ANA profile, and anti neutrophil cytoplasmic antibody profile. Results: One month after the first dose, ANAs at a titer of 1:100 and aCL IgG at 23.7 IgM phospholipid units were detected in 4 children and 1 child, respectively. Of the ANA-positive children, 1 also had ASMA positivity, and another had perinuclear and cytoplasmic ANCA positivity. After the second dose, 3 of the children had aCL IgM. In addition, 2 distinct children had positive anti-thyroid microsomal antibodies and ANA after the second dose. The presence of these autoantibodies following vaccination was statistically significant (P=.002). At month 12 of the study, only 2 children continued to be ANA-positive at the same titer as after the first vaccine dose. Conclusions: Although HAV can induce the production of autoantibodies, none of the children developed autoimmune disorders. Longterm follow up is necessary to check whether autoimmune disorders develop in children who still have ANA. Genetic, immunological, environmental, and hormonal factors are also important in the development of vaccine-induced autoimmunity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1018-9068 1698-0808 |
| العلاقة: | Makale - Uluslararası Hakemli Dergi; Journal of Investigational Allergology and Clinical Immunology; Karalı, Z. vd. (2011). "Autoimmunity and hepatitis a vaccine in children". Journal of Investigational Allergology and Clinical Immunology, 21(5), 389-393.; https://pubmed.ncbi.nlm.nih.gov/21905502Test/; http://hdl.handle.net/11452/23923Test; 000295388600007; 2-s2.0-80051775112; 389; 393; 21 |
| الإتاحة: | http://hdl.handle.net/11452/23923Test https://pubmed.ncbi.nlm.nih.gov/21905502Test/ |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.4F9D16E9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10189068 16980808 |
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