دورية أكاديمية
Hair testing for 3-fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose
| العنوان: | Hair testing for 3-fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose |
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| المؤلفون: | Larabi, Islam Amine, Martin, Marie, Fabresse, Nicolas, Etting, Isabelle, Edel, Yve, Pfau, Gregory, Alvarez, Jean Claude |
| المساهمون: | Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Raymond Poincaré AP-HP, CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| المصدر: | ISSN: 1860-8965. |
| بيانات النشر: | HAL CCSD Springer Verlag |
| سنة النشر: | 2020 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | 3-Fluorofentanyl, Authentic hair analysis, Carfentanil, LC–MS/MS, Methoxyacetylfentanyl, Repetitive exposure to several fentanyls, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Purpose: To demonstrate the usefulness of hair testing to determine exposure pattern to fentanyls. Methods: A 43-year-old male was found unconscious with respiratory depression 15 min after snorting 3 mg of a powder labeled as butyrylfentanyl. He was discharged from hospital within 2 days without blood or urine testing. Two locks of hair were sampled 1 month (M1 A: 0–2 cm (overdose time frame); B: 2–4 cm; C: 4–6 cm) and 1 year (Y1: A: 0–2 cm; B: 2–4 cm) later to monitor his exposure to drugs of abuse by liquid chromatography–tandem mass spectrometry after liquid-liquid extraction. Results: Hair analysis at M1 showed a repetitive exposure to 3-fluorofentanyl (A/B/C: 150/80/60 pg/mg) with higher concentration in segment A reflecting the overdose period. The non-detection of butyrylfentanyl was consistent with the analysis of the recovered powder identified as 3-fluorofentanyl. Furanylfentanyl (40/20/15 pg/mg) and fentanyl (37/25/3 pg/mg) were also detected in hair. The second hair analysis at Y1 showed the use of three new fentanyls, with probably repetitive exposures to methoxyacetylfentanyl (A/B: 500/600 pg/mg), and single or few exposures to carfentanil (2.5/3 pg/mg) and acetyl fentanyl (1/1 pg/mg). A decreasing exposure to 3-fluorofentanyl (25/80 pg/mg), and increasing consumption of furanylfentanyl (310/500 pg/mg) and fentanyl (620/760 pg/mg) were also observed despite methadone treatment initiation. The patient claimed not consuming three out of the six detected fentanyls. Conclusions: We report single or repetitive exposure to several fentanyls using hair testing. To our knowledge, this is the first demonstration of 3-fluorofentanyl and methoxyacetylfentanyl in hair samples collected from an authentic abuser. © 2019, The Author(s). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02950899; https://hal.uvsq.fr/hal-02950899Test; https://hal.uvsq.fr/hal-02950899/documentTest; https://hal.uvsq.fr/hal-02950899/file/Larabi2020_Article_HairTestingFor3-fluorofentanyl.pdfTest |
| DOI: | 10.1007/s11419-019-00502-0 |
| الإتاحة: | https://doi.org/10.1007/s11419-019-00502-0Test https://hal.uvsq.fr/hal-02950899Test https://hal.uvsq.fr/hal-02950899/documentTest https://hal.uvsq.fr/hal-02950899/file/Larabi2020_Article_HairTestingFor3-fluorofentanyl.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.4F1C126A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11419-019-00502-0 |
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