صورة
Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer - Supplementary Information.docx ...
| العنوان: | Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer - Supplementary Information.docx ... |
|---|---|
| المؤلفون: | Chaube, Udit, Dey, Rajdeep, Shaw, Suman, Patel, Bhumika D, Bhatt, Hardik G |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2022 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| الوصف: | Figure SF 01 Lung cancer and its classification Figure SF 02 Structure of mTOR backbone, which consists of six region the HEAT, FAT (domain focal adhesion targeting domain), FRB (FKBP12 rapamycin binding), KIN (kinase, the target of ATP competitive inhibitors), NRD, and FATC (focal adhesion targeting domain of C-terminal). & Structures of mTORC1 (mTOR complex)1/2. mTORC1 which contains of the mTOR backbone, Raptor, Deptor, mLST8, PRAS40, and mTORC2, which contains of mTOR backbone, Protor, Rictor, Deptor, mSlN1, and mLST8. Figure SF 03 Structure of some “nib” group of molecules like some EGFR inhibitors viz. 29. Erlotinib & 30. Gifitinib, a tyrosine kinase inhibitor 31. Neratinib, a MEK kinase inhibitor 32. Selumetinib, 33. Cobimetinib/GDC-0973, an ERK inhibitor 34. Trametinib all are used to treat lung cancers. Figure SF 04 Timeline indicates tetrahydroquinoline derivatives either as a mTOR inhibitor or for the treatment of lung cancer in last ten years. Table ST 01 Some known mTOR inhibitors ... |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://dx.doi.org/10.4155/fmc-2022-0204Test |
| DOI: | 10.25402/fmc.21758360 |
| الإتاحة: | https://doi.org/10.25402/fmc.2175836010.4155/fmc-2022-0204Test https://tandf.figshare.com/articles/figure/Tetrahydroquinoline_an_efficient_scaffold_as_mTOR_inhibitor_for_the_treatment_of_lung_cancer_-_Supplementary_Information_docx/21758360Test |
| حقوق: | Creative Commons Attribution Non Commercial No Derivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/legalcodeTest ; cc-by-nc-nd-4.0 |
| رقم الانضمام: | edsbas.4EFBE5CE |
| قاعدة البيانات: | BASE |
| DOI: | 10.25402/fmc.21758360 |
|---|