دورية أكاديمية
One-day prevalence of asymptomatic carriage of toxigenic and non-toxigenic Clostridioides difficile in 10 French hospitals
| العنوان: | One-day prevalence of asymptomatic carriage of toxigenic and non-toxigenic Clostridioides difficile in 10 French hospitals |
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| المؤلفون: | Le Monnier, Alban, Candela, T., Mizrahi, A., Bille, E., Bourgeois-Nicolaos, N., Cattoir, V., Farfour, E., Grall, I., Lecointe, D., Limelette, A., Marcade, G., Poilane, I., Poupy, P., Kansau, I., Zahar, J-R, Pilmis, B., Hartmann, C., Kazhalawi, A., Lambert-Bordes, S., Bleunven, S., Bedos, J.-P., Greder-Belan, A., Rigaudea, S., Lecuyer, H., Jousset, A., Lebeaux, D., Levy, B., Rabate, C., Collignon, A., Batah, J., Francois, V., Sebbane, G., Woerther, P.-L., Loggia, G., Michon, J., Verdon, R., Samba, D., Méar, J.-B., Guillard, T., Nguyen, Y., Banisadr, F., Delmer, A., Himberlin, C., Diallo, S., Furet, I., Achouri, B., Reksa, A., Jouveshomme, S., Menage, E., Philippart, F., Hadj-Abdeslam, M., Durand-Gasselin, B., Eveillard, M., Kouatchet, A., Schmidt, A., Salanoubat, C., Heurtaux, M.-N., Cronier, P., Foufa, A. |
| المساهمون: | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupe Hospitalier Paris Saint-Joseph (hpsj), Université Paris-Saclay, Laboratoire de Microbiologie Clinique AP-HP Hôpital Necker-Enfants Malades, Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP - Hôpital Antoine Béclère Clamart, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP. Université Paris Saclay, Département de Chirurgie CHU Caen, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Foch Suresnes, Ramsay Générale de Santé - Hôpital Privé La Louvière, Hôpital Sud Francilien Corbeil Essonne, Hôpital universitaire Robert Debré Reims, Hôpital Louis Mourier - AP-HP Colombes, Hôpital Jean Verdier AP-HP, Centre Hospitalier de Versailles André Mignot (CHV), Endocrinologie pédiatrique CHU Angers, Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM) |
| المصدر: | ISSN: 0195-6701. |
| بيانات النشر: | HAL CCSD WB Saunders |
| سنة النشر: | 2022 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Asymptomatic carriage, Clostridioides difficile, One-day prevalence study, Risk factors, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| الوصف: | International audience ; Background: Asymptomatic faecal carriage of Clostridioides difficile has been widely evaluated, but its prevalence across a wide range of clinical departments and related risk factors are not well described. The objectives of the PORTADIFF study were to evaluate the prevalence and identifying risk factors leading to asymptomatic carriage of both toxigenic and non-toxigenic C. difficile.Methods: The PORTADIFF study was a 1-day prevalence study carried out in 10 different French hospitals. Adult patients, who agreed to participate, were included in this study and provided a fresh stool sample. C. difficile strains isolated from carriage were characterized by polymerase chain reaction (PCR) detection of tcdA, tcdB, cdtA and cdtB, and PCR ribotyping.Results: In total, 721 patients were included in this study. The median age was 73 years (range 18-101 years) and the male/female ratio was 1.06. C. difficile (either toxigenic or non-toxigenic strains) was isolated from 79 (11%) patients; 42 (5.8%) strains were toxigenic. The prevalence rates of asymptomatic carriage ranged from 5% on surgical wards to 19% on long-term care wards. The main risk factors associated with asymptomatic carriage were antibiotic treatment within the preceding 3 months (81.8% vs 53.7%; P<0.01), hospitalization within the preceding 2 months (55.8% vs 33%; P<0.01), cumulative duration of hospital stay before study inclusion (mean 50.1 vs 34.5 days; P<0.047), and hospitalization on a ward with high global incidence of C. difficile infection.Conclusion: Eleven percent of hospitalized patients were asymptomatic carriers of toxigenic or non-toxigenic C. difficile, and may constitute a potential reservoir of C. difficile strains. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35640734; hal-04068142; https://hal.science/hal-04068142Test; PUBMED: 35640734; WOS: 000880110800010 |
| DOI: | 10.1016/j.jhin.2022.05.011 |
| الإتاحة: | https://doi.org/10.1016/j.jhin.2022.05.011Test https://hal.science/hal-04068142Test |
| حقوق: | http://hal.archives-ouvertes.fr/licences/copyrightTest/ |
| رقم الانضمام: | edsbas.4EC58F03 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jhin.2022.05.011 |
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