دورية أكاديمية
Time Since Stroke Onset, Quantitative Collateral Score, and Functional Outcome After Endovascular Treatment for Acute Ischemic Stroke
| العنوان: | Time Since Stroke Onset, Quantitative Collateral Score, and Functional Outcome After Endovascular Treatment for Acute Ischemic Stroke |
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| المؤلفون: | Uniken Venema, Simone M., Wolff, Lennard, van den Berg, Sophie A., Reinink, Hendrik, Luijten, Sven P.R., Lingsma, Hester F., Marquering, Henk A., Boers, Anna M.M., Bot, Joost, Hammer, Sebastiaan, Nederkoorn, Paul J., Roos, Yvo B.W.E.M., Majoie, Charles B.L.M., Dankbaar, Jan Willem, van der Lugt, Aad, van der Worp, H. Bart |
| المصدر: | Uniken Venema , S M , Wolff , L , MR CLEAN Registry Investigators , van den Berg , S A , Reinink , H , Luijten , S P R , Lingsma , H F , Marquering , H A , Boers , A M M , Bot , J , Hammer , S , Nederkoorn , P J , Roos , Y B W E M , Majoie , C B L M , Dankbaar , J W , van der Lugt , A & van der Worp , H B 2022 , ' Time Since Stroke .... |
| سنة النشر: | 2022 |
| الوصف: | BACKGROUND AND OBJECTIVES: In patients with ischemic stroke undergoing endovascular treatment (EVT), time to treatment and collateral status are important prognostic factors and may be correlated. We aimed to assess the relation between time to CT angiography (CTA) and a quantitatively determined collateral score and to assess whether the collateral score modified the relation between time to recanalization and functional outcome. METHODS: We analyzed data from patients with acute ischemic stroke included in the Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke Registry between 2014 and 2017, who had a carotid terminus or M1 occlusion and were treated with EVT within 6.5 hours of symptom onset. A quantitative collateral score (qCS) was determined from baseline CTA using a validated automated image analysis algorithm. We also determined a 4-point visual collateral score (vCS). Multivariable regression models were used to assess the relations between time to imaging and the qCS and between the time to recanalization and functional outcome (90-day modified Rankin Scale score). An interaction term (time to recanalization × qCS) was entered in the latter model to test whether the qCS modifies this relation. Sensitivity analyses were performed using the vCS. RESULTS: We analyzed 1,813 patients. The median time from symptom onset to CTA was 91 minutes (interquartile range [IQR] 65-150 minutes), and the median qCS was 49% (IQR 25%-78%). Longer time to CTA was not associated with the log-transformed qCS (adjusted β per 30 minutes, 0.002, 95% CI -0.006 to 0.011). Both a higher qCS (adjusted common odds ratio [acOR] per 10% increase: 1.06, 95% CI 1.03-1.09) and shorter time to recanalization (acOR per 30 minutes: 1.17, 95% CI 1.13-1.22) were independently associated with a shift toward better functional outcome. The qCS did not modify the relation between time to recanalization and functional outcome (p for interaction: 0.28). Results from sensitivity analyses using the vCS were ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.eur.nl/en/publications/a90cb04a-0798-4fd3-8287-5668fe20c5b3Test |
| DOI: | 10.1212/WNL.0000000000200968 |
| الإتاحة: | https://doi.org/10.1212/WNL.0000000000200968Test https://pure.eur.nl/en/publications/a90cb04a-0798-4fd3-8287-5668fe20c5b3Test https://pure.eur.nl/ws/files/68778994/e1609.full.pdfTest http://www.scopus.com/inward/record.url?scp=85139573031&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4EAF1496 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1212/WNL.0000000000200968 |
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