دورية أكاديمية
Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data.
| العنوان: | Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. |
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| المؤلفون: | Jolliffe, DA, Greenberg, L, Hooper, RL, Griffiths, CJ, Camargo, CA, Kerley, CP, Jensen, ME, Mauger, D, Stelmach, I, Urashima, M, Martineau, AR |
| سنة النشر: | 2017 |
| المجموعة: | Queen Mary University of London: Queen Mary Research Online (QMRO) |
| مصطلحات موضوعية: | Adolescent, Adrenal Cortex Hormones, Adult, Aged, 80 and over, Anti-Asthmatic Agents, Asthma, Child, Preschool, Dietary Supplements, Disease Progression, Female, Humans, Male, Middle Aged, Secondary Prevention, Treatment Outcome, Vitamin D, Vitamins, Young Adult |
| الوصف: | BACKGROUND: A previous aggregate data meta-analysis of randomised controlled trials showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids. Whether this effect is restricted to patients with low baseline vitamin D status is unknown. METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016. We analysed individual participant data requested from the principal investigator for each eligible trial, adjusting for age and sex, and clustering by study. The primary outcome was the incidence of asthma exacerbation requiring treatment with systemic corticosteroids. Mixed-effects regression models were used to obtain the pooled intervention effect with a 95% CI. Subgroup analyses were done to determine whether effects of vitamin D on risk of asthma exacerbation varied according to baseline 25-hydroxyvitamin D (25[OH]D) concentration, age, ethnic or racial origin, body-mass index, vitamin D dosing regimen, use of inhaled corticosteroids, or end-study 25(OH)D levels; post-hoc subgroup analyses were done according to sex and study duration. This study was registered with PROSPERO, number CRD42014013953. FINDINGS: Our search identified 483 unique studies, eight of which were eligible randomised controlled trials (total 1078 participants). We sought individual participant data for each and obtained it for seven studies (955 participants). Vitamin D supplementation reduced the rate of asthma exacerbation requiring treatment with systemic corticosteroids among all participants (adjusted incidence rate ratio [aIRR] 0·74, 95% CI 0·56-0·97; p=0·03; 955 participants in seven ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 881 - 890 |
| اللغة: | English |
| العلاقة: | Lancet Respir Med; http://qmro.qmul.ac.uk/xmlui/handle/123456789/26923Test |
| DOI: | 10.1016/S2213-2600(17)30306-5 |
| الإتاحة: | https://doi.org/10.1016/S2213-2600Test(17)30306-5 http://qmro.qmul.ac.uk/xmlui/handle/123456789/26923Test |
| حقوق: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.4E9E8DA4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S2213-2600(17)30306-5 |
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