دورية أكاديمية
N 1 -methylpseudouridylation of mRNA causes +1 ribosomal frameshifting
| العنوان: | N 1 -methylpseudouridylation of mRNA causes +1 ribosomal frameshifting |
|---|---|
| المؤلفون: | Mulroney, Thomas E., Pöyry, Tuija, Yam-Puc, Juan Carlos, Rust, Maria, Harvey, Robert F., Kalmar, Lajos, Horner, Emily, Booth, Lucy, Ferreira, Alexander P., Stoneley, Mark, Sawarkar, Ritwick, Mentzer, Alexander J., Lilley, Kathryn S., Smales, C. Mark, von der Haar, Tobias, Turtle, Lance, Dunachie, Susanna, Klenerman, Paul, Thaventhiran, James E. D., Willis, Anne E. |
| بيانات النشر: | Nature Publishing Group UK Nature |
| سنة النشر: | 2024 |
| المجموعة: | Apollo - University of Cambridge Repository |
| الوصف: | Acknowledgements: A.E.W. and T.P. are supported by the Medical Research Council, grant number MC_UU_00025/7(A.E.W.). J.C.Y.-P., E.H., A.P.F. and J.E.D.T. are supported by the Medical Research Council (RG95376 and MC_UU_00025/12). T.E.M. was financially supported by the Integrative Toxicology Training Partnership. T.E.M., M.R., T.V.d.H., C.M.S., J.E.D.T., K.S.L. and A.E.W. acknowledge funding from Wellcome Leap as part of the R3 Program. PITCH was funded by the UK Department of Health and Social Care and UKRI (MR/W02067X/1 and MR/X009297/1), with contributions from UKRI/NIHR through the UK Coronavirus Immunology Consortium (UK-CIC), the Huo Family Foundation and The National Institute for Health Research (COV19-RECPLAS). In Liverpool PITCH is a sub-study of UKHSA’s SIREN study. P.K. is an NIHR Senior Investigators and is funded by WT109965MA. S.J.D. is funded by an NIHR Global Research Professorship (NIHR300791). L.T. is supported by the Wellcome Trust (grant number 205228/Z/16/Z), the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Emerging and Zoonotic Infections (EZI) (NIHR200907) and the Centre of Excellence in Infectious Diseases Research (CEIDR) and the Alder Hey Charity. This research was supported by the NIHR Cambridge Biomedical Research Centre (NIHR203312). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The authors thank the MRC Toxicology Unit Proteomics Facility for assistance with mass spectrometry analysis and A. Chong and D. Launer for assistance with DNA extraction and HLA typing. ; In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect1, 2. Modified ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/xml; application/zip; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/362966Test |
| الإتاحة: | https://www.repository.cam.ac.uk/handle/1810/362966Test |
| رقم الانضمام: | edsbas.4E98BD7E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |