دورية أكاديمية
Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels
| العنوان: | Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels |
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| المؤلفون: | André, Mathilde, Brucato, Nicolas, Hudjasov, Georgi, Pankratov, Vasili, Yermakovich, Danat, Montinaro, Francesco, Kreevan, Rita, Kariwiga, Jason, Muke, John, Boland, Anne, Deleuze, Jean-François, Meyer, Vincent, Evans, Nicholas, Cox, Murray, P, Leavesley, Matthew, Dannemann, Michael, Org, Tõnis, Metspalu, Mait, Mondal, Mayukh, Ricaut, François-Xavier |
| المساهمون: | University of Tartu, Centre de Recherche sur la Biodiversité et l'Environnement (CRBE), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), University of Papua New Guinea (UPNG), The University of Queensland (UQ All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations ), Papua New Guinea (PNG) National Agricultural Research Institute, Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Australian National University (ANU), Massey University, University of Auckland Auckland, James Cook University (JCU), University of Wollongong Australia, Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel (CAU) |
| المصدر: | ISSN: 2041-1723. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology |
| الوصف: | International audience ; Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia and environment-specific pathogen exposure, respectively. In this study, we explored the top genomics regions and the candidate driver SNPs for selection in these two populations using newly sequenced whole-genomes of 54 highlanders and 74 lowlanders. We identified two candidate SNPs under selection - one in highlanders, associated with red blood cell traits and another in lowlanders, which is associated with white blood cell count – both potentially influencing the heart rate of Papua New Guineans in opposite directions. We also observed four candidate driver SNPs that exhibit linkage disequilibrium with an introgressed haplotype, highlighting the need to explore the possibility of adaptive introgression within these populations. This study reveals that the signatures of positive selection in highlanders and lowlanders of Papua New Guinea align closely with the challenges they face, which are specific to their environments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38688933; hal-04616627; https://hal.science/hal-04616627Test; https://hal.science/hal-04616627/documentTest; https://hal.science/hal-04616627/file/PROOF%2041467_2024_47735_Author.pdfTest; PUBMED: 38688933; PUBMEDCENTRAL: PMC11061283 |
| DOI: | 10.1038/s41467-024-47735-1 |
| الإتاحة: | https://doi.org/10.1038/s41467-024-47735-1Test https://hal.science/hal-04616627Test https://hal.science/hal-04616627/documentTest https://hal.science/hal-04616627/file/PROOF%2041467_2024_47735_Author.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.4E5E81C3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-024-47735-1 |
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