دورية أكاديمية
Serum inhibin A and B concentrations during the menstrual cycle in mothers of spontaneous dizygotic twins
| العنوان: | Serum inhibin A and B concentrations during the menstrual cycle in mothers of spontaneous dizygotic twins |
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| المؤلفون: | Gilfillan, Christopher P., Montgomery, Grant W., Zhu, Gu, Martin, Nicholas G., Groome, N. P., Robertson, David M. |
| المساهمون: | N. G. Martin, K. M. Kirk |
| بيانات النشر: | Australian Academic Press |
| سنة النشر: | 2003 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Genetics & Heredity, Obstetrics & Gynecology, Reproductive Biology, Follicle-stimulating-hormone, Bone Morphogenetic Protein-15, Increased Ovulation Rate, Dimeric Inhibin, Growth, Sheep, Gene, Physiology, Selection, Mutations, 321011 Medical Genetics, C1, 730107 Inherited diseases (incl. gene therapy) |
| الوصف: | Dizygotic twinning in humans is influenced by genetic factors suggesting inherited variation affects follicle development and predisposes to double ovulations. In a previous study, we conducted a detailed examination of follicle development and variation in hormone concentrations during the menstrual cycle in mothers of DZ twins (MODZT) compared with an age-matched control group of mothers of singletons. We did not detect differences in FSH concentrations between mothers of twins and mothers of singletons. Serum inhibin concentrations were measured by a radioimmunoassay that did not distinguish between dimeric inhibin A and B forms and free inhibin alpha subunit. We therefore analyzed the samples from this study with specific assays to determine whether concentrations of inhibin A and B were different between MODZT and controls and therefore contribute to the twinning phenotype. There were no significant differences between MONT with single ovulations and control women in inhibin A and B concentrations during the cycle, including the critical period for the selection of the dominant follicle. These data suggest that the genetic cause of twinning is not associated with changes in FSH concentrations or recognised feedback mechanisms regulating FSH release. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1369-0523 |
| العلاقة: | orcid:0000-0002-4140-8139; orcid:0000-0003-4069-8020 |
| الإتاحة: | https://doi.org/10.1375/136905203762687870Test https://espace.library.uq.edu.au/view/UQ:65032Test |
| رقم الانضمام: | edsbas.4E0A15C8 |
| قاعدة البيانات: | BASE |
| تدمد: | 13690523 |
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