دورية أكاديمية
Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study
| العنوان: | Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study |
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| المساهمون: | College of Medicine, Dept. of Preventive Medicine, Hyungseon Yeom, Hyeon Chang Kim, Ju-Mi Lee, Yongwoo Jeon, Il Suh, Kim, Hyeon Chang, Suh, Il, Yeom, Hyung Seon, Jeon, Yongwoo |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adolescent, Adulthood, High density lipoprotein cholesterol, Hypertension, List of abbreviations, TG: triglyceride, HDL-C: high density lipoprotein cholesterol, SBP: systolic blood pressure, DBP: diastolic blood pressure, BMI: body mass index, Triglyceride |
| الوصف: | BACKGROUND: The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio associated with hypertension in adults. However, whether the TG/HDL-C ratio in adolescents predicts future hypertension remains unclear. Here, we evaluated the prospective association between the TG/HDL-C ratio in adolescents and hypertension in early adulthood. METHODS: The Kangwha Study is an ongoing prospective cohort study that has tracked the blood pressure of first grade elementary school students since 1986. We followed up 272 participants who completed health examinations at the age of 16 and 35 years. We excluded 27 participants with adolescent hypertension, defined as those whose blood pressures were above the age- and sex-specific 95th percentiles of the Korean population, and finally analysed 245 participants. We defined high and low TG/HDL-C ratio groups according to the age- and sex-specific 75th percentile of the TG/HDL-C ratio (1.04 for boys and 0.81 for girls) of the Korean population. Adult hypertension was defined by a systolic/diastolic blood pressure�됤돟��140/90 mmHg or by taking antihypertensive medication at the age of 35 years. Logistic regression analysis was performed to evaluate the association between adolescent TG/HDL-C ratio and adult hypertension after adjusting for age at follow-up, sex, baseline systolic blood pressure, waist circumference, and total cholesterol and fasting glucose levels. RESULTS: During the 20-year follow-up, 11 (18.3%) individuals developed hypertension in the high TG/HDL-C ratio group and 10 (5.4%) individuals developed hypertension in the low TG/HDL-C ratio group. The adjusted odds ratio for incident hypertension in the high TG/HDL-C ratio group, compared with the low TG/HDL-C ratio group, was 3.40 (95% confidence interval 1.24-9.31). CONCLUSIONS: High TG/HDL-C ratio in adolescence is associated with hypertension in early adulthood. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1476-511X |
| العلاقة: | LIPIDS IN HEALTH AND DISEASE; J02169; OAK-2018-03987; https://ir.ymlib.yonsei.ac.kr/handle/22282913/163469Test; T201802864; LIPIDS IN HEALTH AND DISEASE, Vol.17 : 212, 2018 |
| DOI: | 10.1186/s12944-018-0861-y |
| الإتاحة: | https://doi.org/10.1186/s12944-018-0861-yTest https://ir.ymlib.yonsei.ac.kr/handle/22282913/163469Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.4DEFC098 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1476511X |
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| DOI: | 10.1186/s12944-018-0861-y |