التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_1_Age-dependent acquisition of IgG antibodies to Shigella serotypes—a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination.pdf |
| المؤلفون: |
Melissa C. Kapulu, Esther Muthumbi, Edward Otieno, Omar Rossi, Pietro Ferruzzi, Francesca Necchi, Alessandra Acquaviva, Laura B. Martin, Benedict Orindi, Kennedy Mwai, Hillary Kibet, Alfred Mwanzu, Godfrey M. Bigogo, Jennifer R. Verani, Cecilia Mbae, Christopher Nyundo, Charles N. Agoti, Usman Nasir Nakakana, Valentino Conti, Philip Bejon, Samuel Kariuki, J. Anthony G. Scott, Francesca Micoli, Audino Podda |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, Shigella flexneri, Shigella sonnei, sero-prevalence, serotype, Kenya, IgG antibodies |
| الوصف: |
Background Shigellosis mainly affects children under 5 years of age living in low- and middle-income countries, who are the target population for vaccination. There are, however, limited data available to define the appropriate timing for vaccine administration in this age group. Information on antibody responses following natural infection, proxy for exposure, could help guide vaccination strategies. Methods We undertook a retrospective analysis of antibodies to five of the most prevalent Shigella serotypes among children aged <5 years in Kenya. Serum samples from a cross-sectional serosurvey in three Kenyan sites (Nairobi, Siaya, and Kilifi) were analyzed by standardized ELISA to measure IgG against Shigella sonnei and Shigella flexneri 1b, 2a, 3a, and 6. We identified factors associated with seropositivity to each Shigella serotype, including seropositivity to other Shigella serotypes. Results A total of 474 samples, one for each participant, were analyzed: Nairobi (n = 169), Siaya (n = 185), and Kilifi (n = 120). The median age of the participants was 13.4 months (IQR 7.0–35.6), and the male:female ratio was 1:1. Geometric mean concentrations (GMCs) for each serotype increased with age, mostly in the second year of life. The overall seroprevalence of IgG antibodies increased with age except for S. flexneri 6 which was high across all age subgroups. In the second year of life, there was a statistically significant increase of antibody GMCs against all five serotypes (p = 0.01–0.0001) and a significant increase of seroprevalence for S. flexneri 2a (p = 0.006), S. flexneri 3a (p = 0.006), and S. sonnei (p = 0.05) compared with the second part of the first year of life. Among all possible pairwise comparisons of antibody seropositivity, there was a significant association between S. flexneri 1b and 2a (OR = 6.75, 95% CI 3–14, p < 0.001) and between S. flexneri 1b and 3a (OR = 23.85, 95% CI 11–54, p < 0.001). Conclusion Children living in low- and middle-income settings such as Kenya are exposed to ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/DataSheet_1_Age-dependent_acquisition_of_IgG_antibodies_to_Shigella_serotypes_a_retrospective_analysis_of_seroprevalence_in_Kenyan_children_with_implications_for_infant_vaccination_pdf/25123379Test |
| DOI: |
10.3389/fimmu.2024.1340425.s001 |
| الإتاحة: |
https://doi.org/10.3389/fimmu.2024.1340425.s001Test
https://figshare.com/articles/dataset/DataSheet_1_Age-dependent_acquisition_of_IgG_antibodies_to_Shigella_serotypes_a_retrospective_analysis_of_seroprevalence_in_Kenyan_children_with_implications_for_infant_vaccination_pdf/25123379Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.4D0F3151 |
| قاعدة البيانات: |
BASE |
