دورية أكاديمية
Divergent strains of human T-lymphotropic virus type 1 (HTLV-1) within the Cosmopolitan subtype in Argentina
| العنوان: | Divergent strains of human T-lymphotropic virus type 1 (HTLV-1) within the Cosmopolitan subtype in Argentina |
|---|---|
| المؤلفون: | Eirin, Maria Emilia, Dilernia, Darío Alberto, Berini, Carolina Andrea, Jones, Leandro Roberto, Pando, María de los Ángeles, Biglione, Mirna Marcela |
| بيانات النشر: | Mary Ann Liebert |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | HTLV-1, DIVERGENT, PHYLOGENY, https://purl.org/becyt/ford/1.6Test, https://purl.org/becyt/ford/1Test |
| الوصف: | HTLV-1 Cosmopolitan subtype Transcontinental subgroup A has been described among aboriginal communities from the northwest endemic area of Argentina. Moreover, Transcontinental subgroup A and the Japanese subgroup B were reported among blood donors from the nonendemic central region of the country. We carried out the first HTLV-1 phylogenetic study in individuals residing in Buenos Aires capital city. Phylogenetic analysis performed on the LTR region showed that all 44 new strains clustered within the Cosmopolitan subtype, with 42 (95.4%) belonging to Transcontinental subgroup A. Of them, 20 (45.5%) strains grouped in the large Latin American cluster and 4 (9.1%) in the small Latin American cluster. The majority of them belonged to individuals of nonblack origin, grouped with Amerindian strains. Three (6.8%) were closely related to South African references and two monophyletic clusters including only HIV/HTLV-1 coinfected individuals were observed. Interestingly, two (4.5%) new sequences (divergent strains) branched off from all five known Cosmopolitan subgroups in a well-supported clade. In summary, these findings show that HTLV-1 Cosmopolitan subtype Transcontinental subgroup A is infecting residents of Buenos Aires, a nonendemic area of Argentina, and confirm the introduction of divergent strains in the country. ; Fil: Eirin, Maria Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Dilernia, Darío Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Berini, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina ; Fil: Jones, Leandro Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Playa Unión; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina ; Fil: Pando, María de ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0889-2229 |
| العلاقة: | http://hdl.handle.net/11336/100078Test; Eirin, Maria Emilia; Dilernia, Darío Alberto; Berini, Carolina Andrea; Jones, Leandro Roberto; Pando, María de los Ángeles; et al.; Divergent strains of human T-lymphotropic virus type 1 (HTLV-1) within the Cosmopolitan subtype in Argentina; Mary Ann Liebert; Aids Research and Human Retroviruses; 24; 10; 8-2008; 1237-1244; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.1089/aid.2008.0024Test http://hdl.handle.net/11336/100078Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/arTest/ |
| رقم الانضمام: | edsbas.4C0E9260 |
| قاعدة البيانات: | BASE |
| تدمد: | 08892229 |
|---|