دورية أكاديمية
Diabetic neuropathy is characterized by progressive corneal nerve fiber loss in the central and inferior whorl regions
| العنوان: | Diabetic neuropathy is characterized by progressive corneal nerve fiber loss in the central and inferior whorl regions |
|---|---|
| المؤلفون: | Ferdousi, Maryam, Kalteniece, Alise, Petropoulos, Ioannis, Azmi, Shazli, Dhage, Shaishav, Marshall, Andrew, Boulton, Andrew J.M., Efron, Nathan, Faber, Catharina G., Lauria, Giuseppe, Soran, Handrean, Malik, Rayaz A. |
| المصدر: | Investigative Ophthalmology and Visual Science |
| بيانات النشر: | Association for Research in Vision and Ophthalmology Inc. |
| سنة النشر: | 2020 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Corneal confocal microscopy, Corneal nerves, Diabetes mellitus |
| الوصف: | PURPOSE. We hypothesized that longitudinal changes in corneal nerve morphology would differ between the central cornea and inferior whorl in relation to other measures of diabetic neuropathy. METHODS. Thirty patients with diabetes (age: 54.08 ± 15.86, duration: 23.95 ± 14.2, HbA1c: 7.51 ± 1.37) and 19 age-matched healthy controls (age: 49.47 ± 13.25) underwent assessment of neuropathy disability score (NDS), vibration perception threshold (VPT), cold (CPT) and warm (WPT) perception thresholds, peroneal motor nerve conduction velocity (PMNCV), corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL), inferior whorl length (IWL), and the average of CNFL and IWL (ANFL) at baseline and after 1 to 8 years. RESULTS. In patients with diabetes, between baseline and follow-up, there was a significant reduction in CNBD (57.72 ± 30.08 vs. 44.04 ± 23.69; P = 0.02), CNFL (21.77 ± 5.19 vs. 15.65 ± 4.7; P < 0.0001), IWL (24.69 ± 8.67 vs. 14.23 ± 6.13; P < 0.0001), ANFL (23.26 ± 5.53 vs. 15.09 ± 4.48; P < 0.0001), and WPT (43.56 ± 4.43 vs. 40.78 ± 4.93; P = 0.01), and an increase in VPT (12.9 ± 8.96 vs. 13.78 ± 8.99; P = 0.02). There was no significant change in CNFD (27.12 ± 8.2 vs. 25.43 ± 7.11; P = 0.2), NDS (3.38 ± 3.35 vs. 2.61 ± 2.8; P = 0.08), CPT (17.7 ± 10.59 vs. 22.45 ± 9.23; P = 0.06), or PMNCV (42.4 ± 4.21 vs. 42.16 ± 6.3; P = 0.2). CONCLUSIONS. There is evidence of corneal nerve loss in patients with diabetes, particularly at the inferior whorl during follow-up. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/230935/1/i1552_5783_283_1_28560.pdfTest; Ferdousi, Maryam, Kalteniece, Alise, Petropoulos, Ioannis, Azmi, Shazli, Dhage, Shaishav, Marshall, Andrew, Boulton, Andrew J.M., Efron, Nathan, Faber, Catharina G., Lauria, Giuseppe, Soran, Handrean, & Malik, Rayaz A. (2020) Diabetic neuropathy is characterized by progressive corneal nerve fiber loss in the central and inferior whorl regions. Investigative Ophthalmology and Visual Science, 61(3), Article number: 48.; https://eprints.qut.edu.au/230935Test/; Faculty of Health; School of Optometry & Vision Science |
| الإتاحة: | https://doi.org/10.1167/iovs.61.3.48Test https://eprints.qut.edu.au/230935Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; 2020 The Authors ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.4B6C85D9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |