التفاصيل البيبلوغرافية
| العنوان: |
Efficacy and safety of teneligliptin, a dipeptidyl peptidase‐4 inhibitor, combined with metformin in Korean patients with type 2 diabetes mellitus: a 16‐week, randomized, double‐blind, placebo‐controlled phase III trial |
| المؤلفون: |
Kim, M. K., Rhee, E.‐J., Han, K. A., Woo, A. C., Lee, M.‐K., Ku, B. J., Chung, C. H., Kim, K.‐A., Lee, H. W., Park, I. B., Park, J. Y., Chul Jang, H. C., Park, K. S., Jang, W. I., Cha, B. Y. |
| المساهمون: |
Handok Inc., Seoul, Republic of Korea |
| المصدر: |
Diabetes, Obesity and Metabolism ; volume 17, issue 3, page 309-312 ; ISSN 1462-8902 1463-1326 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2015 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
The aim of the present study was to assess the efficacy and safety of teneligliptin in combination with metformin in K orean patients with type 2 diabetes mellitus who were inadequately controlled with metformin monotherapy. Patients [glycated haemoglobin ( HbA1c ) 7.0–10.0%, on stable metformin ≥1000 mg/day] were randomized 2 : 1 to receive 20 mg teneligliptin plus metformin ( n = 136) or placebo plus metformin ( n = 68). The primary endpoint was the change in HbA1c levels from baseline to week 16. The mean baseline HbA1c was 7.9% in the teneligliptin group and 7.8% in the placebo group. The differences between the teneligliptin and placebo groups regarding changes in HbA1c and fasting plasma glucose levels were −0.78 % and −1.24 mmol/l (22.42 mg/dl), respectively, at week 16. The incidence of adverse events was similar between the groups. The addition of teneligliptin once daily to metformin was effective and generally well tolerated in K orean patients with type 2 diabetes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/dom.12424 |
| DOI: |
10.1111/dom.12424/fullpdf |
| الإتاحة: |
https://doi.org/10.1111/dom.12424Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.4AD03926 |
| قاعدة البيانات: |
BASE |
