دورية أكاديمية
Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue
| العنوان: | Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue |
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| المؤلفون: | Kengelbach-Weigand, Annika, Thielen, Carolina, Bäuerle, Tobias, Götzl, Rebekka, Gerber, Thomas, Körner, Carolin, Beier, Justus P., Horch, Raymund E., Boos, Anja M. |
| المصدر: | npj Regenerative Medicine ; volume 6, issue 1 ; ISSN 2057-3995 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell Biology, Developmental Biology, Biomedical Engineering, Medicine (miscellaneous) |
| الوصف: | Tissue engineering principles allow the generation of functional tissues for biomedical applications. Reconstruction of large-scale bone defects with tissue-engineered bone has still not entered the clinical routine. In the present study, a bone substitute in combination with mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) with or without growth factors BMP-2 and VEGF-A was prevascularized by an arteriovenous (AV) loop and transplanted into a critical-size tibia defect in the sheep model. With 3D imaging and immunohistochemistry, we could show that this approach is a feasible and simple alternative to the current clinical therapeutic option. This study serves as proof of concept for using large-scale transplantable, vascularized, and customizable bone, generated in a living organism for the reconstruction of load-bearing bone defects, individually tailored to the patient’s needs. With this approach in personalized medicine for the reconstruction of critical-size bone defects, regeneration of parts of the human body will become possible in the near future. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41536-021-00158-8 |
| الإتاحة: | https://doi.org/10.1038/s41536-021-00158-8Test https://www.nature.com/articles/s41536-021-00158-8.pdfTest https://www.nature.com/articles/s41536-021-00158-8Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.4AC2265F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41536-021-00158-8 |
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