دورية أكاديمية
Characterising B cell expression and prognostic significance in human papillomavirus positive oropharyngeal cancer
| العنوان: | Characterising B cell expression and prognostic significance in human papillomavirus positive oropharyngeal cancer |
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| المؤلفون: | Young, RJ, Angel, C, Bressel, M, Pizzolla, A, Thai, AA, Porceddu, SV, Liu, H, Idrizi, R, Metta, J, Lim, AM, Solomon, BJ, Rischin, D |
| بيانات النشر: | ELSEVIER |
| سنة النشر: | 2024 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | OBJECTIVES: The incidence of human papillomavirus positive oropharyngeal cancer (HPV+OPC) is increasing, and new biomarkers are required to better define prognostic groups and guide treatment. Infiltrating T cells have been well studied in head and neck cancer, however the presence and role of B cells and tertiary lymphoid structures (TLS) in the tumor microenvironment has not, even though the interplay between T and B cells is increasingly being recognised. MATERIALS AND METHODS: Using CD20 immunohistochemistry (IHC) to identify B cells and TLS in a cohort of 159 HPV + OPC patients, we semi-quantitatively scored abundance and location (intra-tumoral or stromal) and correlated findings with patient survival. RESULTS: 32% (51/157) of patients had high intra-tumoral (IT) abundance of CD20+ B cells (≥5%) and this was prognostic for improved overall survival (OS) with an adjusted hazard ratio (HR) of 0.2 (95 % CI 0.0-0.7, p = 0.014). We validated our results in an independent cohort comprising 171 HPV + OPC where 14% (23/171) were IT CD20+ high, again showing improved survival with an adjusted HR for OS of 0.2 (95 % CI 0.0-1.4, p = 0.003). Neither stromal abundance nor the presence of TLS were prognostic in either cohort. B cells were subtyped by multispectral IHC, identifying CD20+CD27+ cells, consistent with memory B cells, as the predominant subtype. Combined with validated biomarker CD103, a marker of tissue-resident memory T cells, IT CD20+ B cells abundance was able to prognostically stratify patients further. CONCLUSIONS: CD20+ B cell abundance has the potential to be used as a biomarker to identify good and poor prognosis HPV + OPC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1368-8375 1879-0593 |
| العلاقة: | NHMRC/1175929; NHMRC/1173450; pii: S1368-8375(24)00005-8; Young, R. J., Angel, C., Bressel, M., Pizzolla, A., Thai, A. A., Porceddu, S. V., Liu, H., Idrizi, R., Metta, J., Lim, A. M., Solomon, B. J. & Rischin, D. (2024). Characterising B cell expression and prognostic significance in human papillomavirus positive oropharyngeal cancer. ORAL ONCOLOGY, 150, https://doi.org/10.1016/j.oraloncology.2024.106687Test.; http://hdl.handle.net/11343/343904Test |
| الإتاحة: | https://doi.org/10.1016/j.oraloncology.2024.106687Test http://hdl.handle.net/11343/343904Test |
| رقم الانضمام: | edsbas.4AB52254 |
| قاعدة البيانات: | BASE |
| تدمد: | 13688375 18790593 |
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