دورية أكاديمية
The yield of long-term electrocardiographic recordings in refractory focal epilepsy
| العنوان: | The yield of long-term electrocardiographic recordings in refractory focal epilepsy |
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| المؤلفون: | van der Lende, Marije, Arends, Johan B., Lamberts, Robert J., Tan, Hanno L., de Lange, Frederik J., Sander, Josemir W., Aerts, Arnaud J., Swart, Henk P., Thijs, Roland D. |
| المصدر: | van der Lende , M , Arends , J B , Lamberts , R J , Tan , H L , de Lange , F J , Sander , J W , Aerts , A J , Swart , H P & Thijs , R D 2019 , ' The yield of long-term electrocardiographic recordings in refractory focal epilepsy ' , Epilepsia , vol. 60 , no. 11 , pp. 2215-2223 . https://doi.org/10.1111/epi.16373Test |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | cardiac arrhythmias, ECG, epilepsy, implantable loop recorders, sudden unexpected death in epilepsy |
| الوصف: | OBJECTIVE: To determine the incidence of clinically relevant arrhythmias in refractory focal epilepsy and to assess the potential of postictal arrhythmias as risk markers for sudden unexpected death in epilepsy (SUDEP). METHODS: We recruited people with refractory focal epilepsy without signs of ictal asystole and who had at least one focal seizure per month and implanted a loop recorder with 2-year follow-up. The devices automatically record arrhythmias. Subjects and caregivers were instructed to make additional peri-ictal recordings. Clinically relevant arrhythmias were defined as asystole ≥ 6 seconds; atrial fibrillation < 55 beats per minute (bpm), or > 200 bpm and duration > 30 seconds; persistent sinus bradycardia < 40 bpm while awake; and second- or third-degree atrioventricular block and ventricular tachycardia/fibrillation. We performed 12-lead electrocardiography (ECG) and tilt table testing to identify non-seizure-related causes of asystole. RESULTS: We included 49 people and accumulated 1060 months of monitoring. A total of 16 474 seizures were reported, of which 4679 were captured on ECG. No clinically relevant arrhythmias were identified. Three people had a total of 18 short-lasting (<6 seconds) periods of asystole, resulting in an incidence of 2.91 events per 1000 patient-months. None of these coincided with a reported seizure; one was explained by micturition syncope. Other non-clinically relevant arrhythmias included paroxysmal atrial fibrillation (n = 2), supraventricular tachycardia (n = 1), and sinus tachycardia with a right bundle branch block configuration (n = 1). SIGNIFICANCE: We found no clinically relevant arrhythmias in people with refractory focal epilepsy during long-term follow-up. The absence of postictal arrhythmias does not support the use of loop recorders in people at high SUDEP risk. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.tue.nl/en/publications/3488157f-f2b9-4080-bcbf-c4f6347b8aaeTest |
| DOI: | 10.1111/epi.16373 |
| الإتاحة: | https://doi.org/10.1111/epi.16373Test https://research.tue.nl/en/publications/3488157f-f2b9-4080-bcbf-c4f6347b8aaeTest https://pure.tue.nl/ws/files/139935828/Lende_et_al_2019_Epilepsia.pdfTest http://www.scopus.com/inward/record.url?scp=85074358919&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4AAF139B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/epi.16373 |
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