دورية أكاديمية
Protein target highlights in CASP15: Analysis of models by structure providers
| العنوان: | Protein target highlights in CASP15: Analysis of models by structure providers |
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| المؤلفون: | Alexander, Leila T., Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A., Bayo, Yusupha, Bhabha, Gira, Breyton, Cécile, Caulton, Simon G., Chen, James, Degroux, Séraphine, Ekiert, Damian C., Erlandsen, Benedikte S., Freddolino, Peter L., Gilzer, Dominic, Greening, Chris, Grimes, Jonathan M., Grinter, Rhys, Gurusaran, Manickam, Hartmann, Marcus D., Hitchman, Charlie J., Keown, Jeremy R., Kropp, Ashleigh, Kursula, Petri, Lovering, Andrew L., Lemaitre, Bruno, Lia, Andrea, Liu, Shiheng, Logotheti, Maria, Lu, Shuze, Markússon, Sigurbjörn, Miller, Mitchell D., Minasov, George, Niemann, Hartmut H., Opazo, Felipe, Phillips, George N., Davies, Owen R., Rommelaere, Samuel, Rosas-Lemus, Monica, Roversi, Pietro, Satchell, Karla, Smith, Nathan, Wilson, Mark A., Wu, Kuan-Lin, Xia, Xian, Xiao, Han, Zhang, Wenhua, Zhou, Z. Hong, Fidelis, Krzysztof, Topf, Maya, Moult, John, Schwede, Torsten |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 2023 |
| المجموعة: | University of Basel: edoc |
| الوصف: | We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0887-3585 1097-0134 |
| العلاقة: | https://edoc.unibas.ch/95444/1/Proteins%20-%202023%20-%20Alexander.pdfTest; Alexander, Leila T. and Durairaj, Janani and Kryshtafovych, Andriy and Abriata, Luciano A. and Bayo, Yusupha and Bhabha, Gira and Breyton, Cécile and Caulton, Simon G. and Chen, James and Degroux, Séraphine and Ekiert, Damian C. and Erlandsen, Benedikte S. and Freddolino, Peter L. and Gilzer, Dominic and Greening, Chris and Grimes, Jonathan M. and Grinter, Rhys and Gurusaran, Manickam and Hartmann, Marcus D. and Hitchman, Charlie J. and Keown, Jeremy R. and Kropp, Ashleigh and Kursula, Petri and Lovering, Andrew L. and Lemaitre, Bruno and Lia, Andrea and Liu, Shiheng and Logotheti, Maria and Lu, Shuze and Markússon, Sigurbjörn and Miller, Mitchell D. and Minasov, George and Niemann, Hartmut H. and Opazo, Felipe and Phillips, George N. and Davies, Owen R. and Rommelaere, Samuel and Rosas-Lemus, Monica and Roversi, Pietro and Satchell, Karla and Smith, Nathan and Wilson, Mark A. and Wu, Kuan-Lin and Xia, Xian and Xiao, Han and Zhang, Wenhua and Zhou, Z. Hong and Fidelis, Krzysztof and Topf, Maya and Moult, John and Schwede, Torsten. (2023) Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . Online ahead of print.; info:pmid/37493353; urn:ISSN:0887-3585; urn:ISSN:1097-0134 |
| DOI: | 10.1002/prot.26545 |
| الإتاحة: | https://doi.org/10.1002/prot.26545Test https://edoc.unibas.ch/95444Test/ https://edoc.unibas.ch/95444/1/Proteins%20-%202023%20-%20Alexander.pdfTest |
| حقوق: | cc_by ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4A97CEA8 |
| قاعدة البيانات: | BASE |
| تدمد: | 08873585 10970134 |
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| DOI: | 10.1002/prot.26545 |