التفاصيل البيبلوغرافية
| العنوان: |
Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2 |
| المؤلفون: |
Shaswath S. Chandrasekar, Yashdeep Phanse, Mariah Riel, Rachel E. Hildebrand, Mostafa Hanafy, Jorge E. Osorio, Sherein S. Abdelgayed, Adel M. Talaat |
| المصدر: |
Viruses; Volume 14; Issue 6; Pages: 1262 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, mucosal immunity, correlate of protection, nanovaccine |
| جغرافية الموضوع: |
agris |
| الوصف: |
Antibody measurements are primarily used to evaluate experimental and approved COVID-19 vaccines, which is unilateral considering our immune responses’ complex nature. Previously, we showed that nanoparticle plasmid DNA adjuvant system, QAC, and MVA based vaccines were immunogenic against SARS-CoV-2. Here, we report on the protective efficacy of systemic humoral and mucosal cell-mediated immune responses in transgenic mice models against SARS-CoV-2 following nanoparticle immunization. Parenteral, intramuscular administration of QAC-based plasmid DNA vaccine-encoding SARS-CoV-2 S and N led to the induction of significant serum neutralizing humoral responses, which reduced viral burden in the lungs and prevented viral dissemination to the brain. In contrast, the mucosal, intranasal administration of a heterologous vaccine elicited significant mucosal cell-mediated immune responses in the lungs that limited lung viral replication. The presented results demonstrate that serum neutralizing humoral and local lung T-cell immune responses are critical for the control of SARS-CoV-2 replication. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
SARS-CoV-2 and COVID-19; https://dx.doi.org/10.3390/v14061262Test |
| DOI: |
10.3390/v14061262 |
| الإتاحة: |
https://doi.org/10.3390/v14061262Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.4A6BCAAB |
| قاعدة البيانات: |
BASE |
