دورية أكاديمية
Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication
| العنوان: | Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication |
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| المؤلفون: | Garcia Vidal, Carolina, Iglesias, María, Puerta Alcalde, Pedro, Mas, Vicente, Cuesta Chasco, Genoveva, García Pouton, Nicole, Varona, Sarai, Pozo, Francisco, Vázquez Morón, Sonia, Marcos, Ma. Angeles, Soriano Viladomiu, Alex, Casas Flecha, Inmaculada, HEMATOCOVID19-Researchers Group |
| المصدر: | Articles publicats en revistes (Fonaments Clínics) |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2022 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, Medicaments antivírics, Hematologia, Immunosupressió, Mutació (Biologia), Antiviral agents, Hematology, Immunosuppression, Mutation (Biology) |
| الوصف: | We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 15 p.; application/pdf |
| اللغة: | English |
| تدمد: | 1664-302X |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2022.826883Test; Frontiers in Microbiology, 2022, vol. 13, p. 826883; https://doi.org/10.3389/fmicb.2022.826883Test; http://hdl.handle.net/2445/197930Test; 730209; 9300893 |
| الإتاحة: | https://doi.org/10.3389/fmicb.2022.826883Test http://hdl.handle.net/2445/197930Test |
| حقوق: | cc-by (c) Garcia Vidal, Carolina et al., 2022 ; https://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4A68E643 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1664302X |
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