دورية أكاديمية
Digital behavioural signatures reveal trans-diagnostic clusters of schizophrenia and Alzheimer's disease patients
| العنوان: | Digital behavioural signatures reveal trans-diagnostic clusters of schizophrenia and Alzheimer's disease patients |
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| المؤلفون: | Kas, Martien J.H., Jongs, Niels, Mennes, Maarten, Penninx, Brenda W.J.H., Arango, Celso, van der Wee, Nic, Winter-van Rossum, Inge, Ayuso-Mateos, Jose Luis, Bilderbeck, Amy C., l'Hostis, Philippe, Beckmann, Christian F., Dawson, Gerard R., Sommer, Bernd, Marston, Hugh M. |
| المصدر: | Kas , M J H , Jongs , N , Mennes , M , Penninx , B W J H , Arango , C , van der Wee , N , Winter-van Rossum , I , Ayuso-Mateos , J L , Bilderbeck , A C , l'Hostis , P , Beckmann , C F , Dawson , G R , Sommer , B & Marston , H M 2024 , ' Digital behavioural signatures reveal trans-diagnostic clusters of schizophrenia and Alzheimer's disease patients ' , European Neuropsychopharmacology , vol. 78 , pp. 3-12 . https://doi.org/10.1016/j.euroneuro.2023.09.010Test |
| سنة النشر: | 2024 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Behaviour, Clustering analysis, Digital phenotyping, Neuro-imaging, Neurology, Psychiatry |
| الوصف: | The current neuropsychiatric nosological categories underlie pragmatic treatment choice, regulation and clinical research but does not encompass biological rationale. However, subgroups of patients suffering from schizophrenia or Alzheimer's disease have more in common than the neuropsychiatric nature of their condition, such as the expression of social dysfunction. The PRISM project presents here initial quantitative biological insights allowing the first steps toward a novel trans-diagnostic classification of psychiatric and neurological symptomatology intended to reinvigorate drug discovery in this area. In this study, we applied spectral clustering on digital behavioural endpoints derived from passive smartphone monitoring data in a subgroup of Schizophrenia and Alzheimer's disease patients, as well as age matched healthy controls, as part of the PRISM clinical study. This analysis provided an objective social functioning characterization with three differential clusters that transcended initial diagnostic classification and was shown to be linked to quantitative neurobiological parameters assessed. This emerging quantitative framework will both offer new ways to classify individuals in biologically homogenous clusters irrespective of their initial diagnosis, and also offer insights into the pathophysiological mechanisms underlying these clusters. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/469c1bcd-53f7-4d22-88a4-9d6763be828aTest |
| DOI: | 10.1016/j.euroneuro.2023.09.010 |
| الإتاحة: | https://doi.org/10.1016/j.euroneuro.2023.09.010Test https://hdl.handle.net/11370/469c1bcd-53f7-4d22-88a4-9d6763be828aTest https://research.rug.nl/en/publications/469c1bcd-53f7-4d22-88a4-9d6763be828aTest https://pure.rug.nl/ws/files/856553876/1-s2.0-S0924977X23006880-main.pdfTest http://www.scopus.com/inward/record.url?scp=85174538020&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.49B1423 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.euroneuro.2023.09.010 |
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