دورية أكاديمية
Study on synthesis and antimicrobial activities of some michael-type addition compounds
| العنوان: | Study on synthesis and antimicrobial activities of some michael-type addition compounds |
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| المؤلفون: | Nzeyimana A., Bayram G., Utku S., Ülger M., Aslan G., Berçin E. |
| بيانات النشر: | University of Ankara |
| سنة النشر: | 2021 |
| المجموعة: | Ege University Institutional Repository |
| مصطلحات موضوعية: | Antifungal activity, 2 amino 3 [[1 (4 methoxyphenyl) 2 nitropropyl]sulfanyl]propanoic acid, 2 amino 3 [[1 (4 methylphenyl) 2 nitropropyl]sulfanyl]propanoic acid, cysteine, Antibacterial activity, Antimycobacterial activity, Michael type addition, ?-methyl-?-nitrostyrene, 2 amino 3 [(2 nitro 1 phenylpropyl)sulfanyl]propanoic acid, 2 amino 3 [(2 nitro 1 phenylpropyl)thio]propanoic acid, 2 amino 3 [[1 (4 chlorophenyl) 2 nitropropyl]sulfanyl]propanoic acid, 2 amino 3 [[1 (4 hydroxy 3 methoxyphenyl) 2 nitropropyl]sulfanyl]propanoic acid, 2 amino 3 [[1 (4 nitrophenyl) 2 nitropropyl]sulfanyl]propanoic acid, 2 amino 3 [[1 [4 (dimethylamino)phenyl] 2 nitropropyl]sulfanyl]propanoic acid, ampicillin, antifungal agent, antiinfective agent, beta methyl beta nitrostyrene derivative, fluconazole, isoniazid, resazurin, rifampicin, styrene derivative, tuberculostatic agent, unclassified drug, antimicrobial activity, Article, Bacillus subtilis, bacterial strain, broth dilution |
| الوصف: | Objective: Multidrug-resistant pathogenic bacteria, fungi, and Mycobacterium tuberculosis infections continue to be increasingly widespread worldwide. In organic chemistry, the tiya-Michael type addition is also significant reaction in the synthesis of bioactive compounds. In this study, the aim is to synthesize the series of new Michael type addition products 2-amino-3-[(2-nitro-1-phenylpropyl)thio]propanoic acid (IIa-IIg) and to investigate their in vitro, antibacterial, antifungal and antitubercular activity. Material and Method: IIa-IIg derivatives were performed combining ?-methyl-?-nitrostyrenes (Ia-Ig) with L-cysteine using Michael addition reaction and characterized by 1HNMR, FTIR, ESI-LC/MS and elemental analysis. Microdilution method and resazurin microtiter assay were used to determine antimicrobial activities. Result and Discussion: Comparing the activities of the synthesized compounds, IIa, IId and IIe were found to have significant activity, with a MIC value of 1.95 µg/ml, against Mycobacterium tuberculosis H37Rv strain. All synthesized novel compounds displayed moderate activity against tested bacterial and fungi strains. Among the synthesized compounds, IIb exhibited the best antibacterial and antifungal activity, with MIC values of 31.25, 31.25 and 15.6 µg/ml, against B. subtilis, E. faecium and C. albicans, respectively. It was clear that some of the synthesized compounds exhibited antimycobacterial activity which could be a very good candidate for clinical uses. © 2021 University of Ankara. All rights reserved. ; This work was supported by the Mersin University Scientific Research Funds (Grant number |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 10153918 |
| العلاقة: | Ankara Universitesi Eczacilik Fakultesi Dergisi; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11454/79911Test; https://doi.org/10.33483/jfpau.867768Test; 45; 182; 193 |
| DOI: | 10.33483/jfpau.867768 |
| الإتاحة: | https://doi.org/10.33483/jfpau.867768Test https://hdl.handle.net/11454/79911Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.494C185B |
| قاعدة البيانات: | BASE |
| تدمد: | 10153918 |
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| DOI: | 10.33483/jfpau.867768 |