دورية أكاديمية
A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project
| العنوان: | A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project |
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| المؤلفون: | Pirazzini C., Azevedo T., Baldelli L., Bartoletti-Stella A., Calandra-Buonaura G., Dal Molin A., Dimitri G. M., Doykov I., Gomez-Garre P., Hagg S., Hallqvist J., Halsband C., Heywood W., Jesus S., Jylhava J., Kwiatkowska K. M., Labrador-Espinosa M. A., Licari C., Maturo M. G., Mengozzi G., Meoni G., Milazzo M., Perinan-Tocino M. T., Ravaioli F., Sala C., Sambati L., Schade S., Schreglmann S., Spasov S., Tenori L., Williams D., Xumerle L., Zago E., Bhatia K. P., Capellari S., Cortelli P., Garagnani P., Houlden H., Lio P., Luchinat C., Delledonne M., Mills K., Mir P., Mollenhauer B., Nardini C., Pedersen N. L., Provini F., Strom S., Trenkwalder C., Turano P., Bacalini M. G., Franceschi C., Adarmes-Gomez A., Bonilla-Toribio M., Boninsegna C., Broli M., Buiza-Rueda D., Carrion-Claro M., Cilea R., Clayton R., Molin A. D., De Luca S., De Massis P., Escuela-Martin R., Fabbri G., Gabellini A., Giuliani C., Guaraldi P., Huertas I., Macias D., Macri S., Magrinelli F., Rodriguez J. F. M., Mignani F., Nassetti S. A., Scaglione C. L. M., Tejera-Parrado C., Valzania F., Ortega R. V. |
| المساهمون: | Pirazzini, C., Azevedo, T., Baldelli, L., Bartoletti-Stella, A., Calandra-Buonaura, G., Dal Molin, A., Dimitri, G. M., Doykov, I., Gomez-Garre, P., Hagg, S., Hallqvist, J., Halsband, C., Heywood, W., Jesus, S., Jylhava, J., Kwiatkowska, K. M., Labrador-Espinosa, M. A., Licari, C., Maturo, M. G., Mengozzi, G., Meoni, G., Milazzo, M., Perinan-Tocino, M. T., Ravaioli, F., Sala, C., Sambati, L., Schade, S., Schreglmann, S., Spasov, S., Tenori, L., Williams, D., Xumerle, L., Zago, E., Bhatia, K. P., Capellari, S., Cortelli, P., Garagnani, P., Houlden, H., Lio, P., Luchinat, C., Delledonne, M., Mills, K., Mir, P., Mollenhauer, B., Nardini, C., Pedersen, N. L., Provini, F., Strom, S., Trenkwalder, C., Turano, P., Bacalini, M. G., Franceschi, C., Adarmes-Gomez, A., Bonilla-Toribio, M., Boninsegna, C., Broli, M., Buiza-Rueda, D., Carrion-Claro, M., Cilea, R., Clayton, R., Molin, A. D., De Luca, S., De Massis, P., Escuela-Martin, R., Fabbri, G., Gabellini, A., Giuliani, C., Guaraldi, P., Huertas, I., Macias, D., Macri, S., Magrinelli, F., Rodriguez, J. F. M., Mignani, F., Nassetti, S. A., Scaglione, C. L. M., Tejera-Parrado, C., Valzania, F., Ortega, R. V. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | Inflammaging, Neurodegeneration, Omic, Parkinson's disease |
| الوصف: | Advanced age is the major risk factor for idiopathic Parkinson's disease (PD), but to date the biological relationship between PD and ageing remains elusive. Here we describe the rationale and the design of the H2020 funded project “PROPAG-AGEING”, whose aim is to characterize the contribution of the ageing process to PD development. We summarize current evidences that support the existence of a continuum between ageing and PD and justify the use of a Geroscience approach to study PD. We focus in particular on the role of inflammaging, the chronic, low-grade inflammation characteristic of elderly physiology, which can propagate and transmit both locally and systemically. We then describe PROPAG-AGEING design, which is based on the multi-omic characterization of peripheral samples from clinically characterized drug-naïve and advanced PD, PD discordant twins, healthy controls and "super-controls", i.e. centenarians, who never showed clinical signs of motor disability, and their offspring. Omic results are then validated in a large number of samples, including in vitro models of dopaminergic neurons and healthy siblings of PD patients, who are at higher risk of developing PD, with the final aim of identifying the molecular perturbations that can deviate the trajectories of healthy ageing towards PD development. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| ردمك: | 978-0-04-763742-1 0-04-763742-0 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33385396; info:eu-repo/semantics/altIdentifier/wos/WOS:000626268000009; volume:194; journal:MECHANISMS OF AGEING AND DEVELOPMENT; info:eu-repo/grantAgreement/EC/H2020/634821; http://hdl.handle.net/11365/1189235Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099396161; https://www.sciencedirect.com/science/article/pii/S0047637420302220?via=ihubTest |
| DOI: | 10.1016/j.mad.2020.111426 |
| الإتاحة: | https://doi.org/10.1016/j.mad.2020.111426Test http://hdl.handle.net/11365/1189235Test https://www.sciencedirect.com/science/article/pii/S0047637420302220?via=ihubTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.48FF55D5 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780047637421 0047637420 |
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| DOI: | 10.1016/j.mad.2020.111426 |