دورية أكاديمية
Proposal for a novel management of indeterminate thyroid nodules on the basis of cytopathological subclasses
| العنوان: | Proposal for a novel management of indeterminate thyroid nodules on the basis of cytopathological subclasses |
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| المؤلفون: | ROSSI, Martina, LUPO, Sabrina, Rossi, Roberta, Franceschetti, Paola, Trasforini, Giorgio, Bruni, Stefania, TAGLIATI, Federico, BURATTO, Mattia, LANZA, Giovanni, DAMIANI, Luca, DEGLI UBERTI, Ettore, ZATELLI, Maria Chiara |
| المساهمون: | Rossi, Martina, Lupo, Sabrina, Rossi, Roberta, Franceschetti, Paola, Trasforini, Giorgio, Bruni, Stefania, Tagliati, Federico, Buratto, Mattia, Lanza, Giovanni, Damiani, Luca, DEGLI UBERTI, Ettore, Zatelli, Maria Chiara |
| سنة النشر: | 2017 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| مصطلحات موضوعية: | Cytological sub-categorie, Indeterminate thyroid nodule, Thyroid nodule clinical risk, Thyroid nodule management, Endocrinology, Diabetes and Metabolism |
| الوصف: | Indeterminate thyroid nodules include heterogeneous lesions that could benefit from a differential management. Our aim is to better define the management of the Bethesda System for Reporting Thyroid Cytopathology class III and IV nodules, by identifying cytological subcategories among Bethesda System for Reporting Thyroid Cytopathology classIII associated with different clinical risk, by means of ultrasound, repeated FNAB, and BRAFV600E molecular analysis. We also evaluated the outcome of nodules not operated, over a 5-year follow-up. Out of 460 nodules (269 Bethesda System for Reporting Thyroid Cytopathology classIII and 191 Bethesda System for Reporting Thyroid Cytopathology classIV), 344 were operated on surgical group and 116 followed-up conservatively (follow-up group). Bethesda System for Reporting Thyroid Cytopathology classIII was divided into four subcategories on the basis of cytomorphological features (III-1, III-2, III-3, III-4). Clinical risk was defined on the basis of histological, cytological, and ultrasound data. Malignancy was higher in Bethesda System for Reporting Thyroid Cytopathology classIII vs. Bethesda System for Reporting Thyroid Cytopathology classIV (34.4 vs. 26.2 %; p < 0.01). Papillary thyroid carcinoma was the most frequent cancer in each Bethesda System for Reporting Thyroid Cytopathology class(35 %). BRAFV600E diagnostic accuracy was 87 %. Repeated FNAB reclassified as benign nearly 40 % of nodules, selecting patients where surgery could be spared. Significant nodule growth occurred in 13.7 % of nodules, belonging mostly to Bethesda System for Reporting Thyroid Cytopathology classIII-2 and Bethesda System for Reporting Thyroid Cytopathology classIV. Overall clinical risk was higher in Bethesda System for Reporting Thyroid Cytopathology III-1, III-4, and IV classes. We propose a differential management of Bethesda System for Reporting Thyroid Cytopathology III and IV classes and related subcategories: surgery may be indicated in Bethesda System for Reporting Thyroid ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27623969; info:eu-repo/semantics/altIdentifier/wos/WOS:000403670300013; volume:57; issue:1; firstpage:98; lastpage:107; numberofpages:10; journal:ENDOCRINE; http://hdl.handle.net/11392/2364795Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84987642729; https://link.springer.com/article/10.1007/s12020-016-1105-4Test |
| DOI: | 10.1007/s12020-016-1105-4 |
| الإتاحة: | https://doi.org/10.1007/s12020-016-1105-4Test http://hdl.handle.net/11392/2364795Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.48D2248E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12020-016-1105-4 |
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