دورية أكاديمية
Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients
| العنوان: | Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients |
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| المؤلفون: | Sotomayor, Camilo G., Gomes-Neto, Antonio W., Gans, Rijk O. B., de Borst, Martin H., Berger, Stefan P., Rodrigo, Ramon, Navis, Gerjan J., Touw, Daan J., Bakker, Stephan J. L. |
| المصدر: | Sotomayor , C G , Gomes-Neto , A W , Gans , R O B , de Borst , M H , Berger , S P , Rodrigo , R , Navis , G J , Touw , D J & Bakker , S J L 2018 , ' Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients ' , Nutrients , vol. 10 , no. 10 , 1419 . https://doi.org/10.3390/nu10101419Test |
| سنة النشر: | 2018 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | fish intake, omega-3 polyunsaturated fatty acids, mercury, cardiovascular mortality, all-cause mortality, renal transplant recipients, AMERICAN-HEART-ASSOCIATION, N-3 FATTY-ACIDS, CARDIOVASCULAR-DISEASE, VENTRICULAR MYOCARDIUM, IN-VITRO, RISK, OMEGA-3-FATTY-ACIDS, CONSUMPTION, PREVENTION, SURVIVAL |
| الوصف: | Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 +/- 13 years-old, 57% men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14-0.63) mu g/L) positively associated with fish intake (std. beta = 0.21, p <0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95% CI 0.58-0.96; and, HR 0.75, 95% CI 0.58-0.97, respectively) and all-cause mortality (HR 0.84, 95% CI 0.72-0.97; and, HR 0.86, 95% CI 0.74-0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/b6328b49-43a4-4f56-92cd-c2f4bf40f17dTest |
| DOI: | 10.3390/nu10101419 |
| الإتاحة: | https://doi.org/10.3390/nu10101419Test https://hdl.handle.net/11370/b6328b49-43a4-4f56-92cd-c2f4bf40f17dTest https://research.rug.nl/en/publications/b6328b49-43a4-4f56-92cd-c2f4bf40f17dTest https://pure.rug.nl/ws/files/65867184/nutrients_10_01419.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.48CF6933 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu10101419 |
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