التفاصيل البيبلوغرافية
| العنوان: |
Expression of sarcosine metabolism-related proteins in estrogen receptor negative breast cancer according to the androgen receptor and HER-2 status |
| المساهمون: |
Min Ju Kim, Woo Hee Jung, Ja Seung Koo, Koo, Ja Seung, Jung, Woo Hee |
| المصدر: |
T201503339.pdf |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Adult, Biomarkers, Tumor/analysis, Breast Neoplasms/chemistry, Breast Neoplasms/enzymology, Breast Neoplasms/mortality, Breast Neoplasms/pathology, Breast Neoplasms/therapy, Carcinoma, Ductal, Breast/chemistry, Breast/enzymology, Breast/mortality, Breast/pathology, Breast/therapy, Disease-Free Survival, Female, Glycine N-Methyltransferase/analysis, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Receptor, ErbB-2/analysis, Receptors, Androgen/analysis, Estrogen/analysis, Estrogen/deficiency, Sarcosine/metabolism, Sarcosine Dehydrogenase/analysis, Sarcosine Oxidase/analysis |
| الوصف: |
The aim of this study is to investigate the expression of sarcosine metabolism related proteins according to androgen receptor (AR) and HER-2 status in estrogen receptor (ER) negative breast cancer and to analyze its clinical implications. Tissue microarray was constructed for a total of 334 cases of ER negative breast cancer. Immunohistochemical stain was conducted for sarcosine metabolism related proteins such as glycine N-methyltransferase (GNMT), sarcosine dehydrogenase (SARDH), and l-pipecolic acid oxidase (PIPOX). There were 131 AR positive, 205 AR negative cases and 143 HER-2 positive, 193 HER-2 negative cases. When subdividing into four groups according to AR and HER-2 status, there were 55 AR(+)/HER-2(-) cases, 76 AR(+)/HER-2(+) cases, 67 AR(-)/HER-2(+) cases and 138 AR(-)/HER-2(-) cases. GNMT and PIPOX expression was highest in the AR(+)/HER-2(-) group while expressed lowest in the AR(-)/HER-2(-) group (P<0.001). Stromal PIPOX expression was highest in the AR(-)/HER-2(+) group and lowest in the AR(-)/HER-2(-) group (P=0.010). GNMT and PIPOX expression was higher in the AR positive group compared with those of AR negative group (P=0.001, and P<0.001, respectively), while tumoral and stromal PIPOX expression showed a significant association with HER-2 positivity (P=0.006, and P=0.005, respectively). AR positive group had the highest ratio of low sarcosine type while the AR negative group had the highest ratio of null type (P<0.001). In conclusion, ER negative breast cancer showed different expression of sarcosine metabolism related proteins according to AR and HER-2 status. GNMT and PIPOX expression was high in the AR positive group while tumoral and stromal PIPOX expression was high in the HER-2 positive group. ; open |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| تدمد: |
1936-2625 |
| العلاقة: |
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY; J01096; OAK-2015-01883; https://ir.ymlib.yonsei.ac.kr/handle/22282913/141043Test; T201503339; INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.8(7) : 7967-7977, 2015; 30477 |
| الإتاحة: |
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141043Test |
| حقوق: |
CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; free |
| رقم الانضمام: |
edsbas.48CC7833 |
| قاعدة البيانات: |
BASE |
