دورية أكاديمية
Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin
| العنوان: | Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin |
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| المؤلفون: | De Matteis, Serena, Scarpi, Emanuela, Granato, Anna Maria, Vespasiani-Gentilucci, Umberto, La Barba, Giuliano, Foschi, Francesco Giuseppe, Bandini, Erika, Ghetti, Martina, Marisi, Giorgia, Cravero, Paola, Gramantieri, Laura, Cucchetti, Alessandro, Ercolani, Giorgio, Santini, Daniele, Frassineti, Giovanni Luca, Faloppi, Luca, Scartozzi, Mario, Cascinu, Stefano, Casadei-Gardini, Andrea |
| المساهمون: | De Matteis, Serena, Scarpi, Emanuela, Granato, Anna Maria, Vespasiani-Gentilucci, Umberto, La Barba, Giuliano, Foschi, Francesco Giuseppe, Bandini, Erika, Ghetti, Martina, Marisi, Giorgia, Cravero, Paola, Gramantieri, Laura, Cucchetti, Alessandro, Ercolani, Giorgio, Santini, Daniele, Frassineti, Giovanni Luca, Faloppi, Luca, Scartozzi, Mario, Cascinu, Stefano, Casadei-Gardini, Andrea |
| سنة النشر: | 2019 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | diabete, metabolic syndrome, metformin, non-alcoholic steatohepatiti, Adult, Aged, 80 and over, Carcinoma, Hepatocellular, Diabetes Mellitus, Type 2, Female, Human, Hypoglycemic Agent, Hypoxia-Inducible Factor 1, alpha Subunit, Liver, Liver Neoplasm, Male, Middle Aged, Sirtuin 3, TOR Serine-Threonine Kinases |
| الوصف: | The incidence of hepatocellular carcinoma deriving from metabolic dysfunctions has increased in the last years. Sirtuin- (SIRT-3), phospho-mammalian target of rapamycin (p-mTOR) and hypoxia-inducible factor- (HIF-1α) are involved in metabolism and cancer. However, their role in hepatocellular carcinoma (HCC) metabolism, drug resistance and progression remains unclear. This study aimed to better clarify the biological and clinical function of these markers in HCC patients, in relation to the presence of metabolic alterations, metformin therapy and clinical outcome. A total of 70 HCC patients were enrolled: 48 and 22 of whom were in early stage and advanced stage, respectively. The expression levels of the three markers were assessed by immunohistochemistry and summarized using descriptive statistics. SIRT-3 expression was higher in diabetic than non-diabetic patients, and in metformin-treated than insulin-treated patients. Interestingly, p-mTOR was higher in patients with metabolic syndrome than those with different etiology, and, similar to SIRT-3, in metformin-treated than insulin-treated patients. Moreover, our results describe a slight, albeit not significant, benefit of high SIRT-3 and a significant benefit of high nuclear HIF-1α expression in early-stage patients, whereas high levels of p-mTOR correlated with worse prognosis in advanced-stage patients. Our study highlighted the involvement of SIRT-3 and p-mTOR in metabolic dysfunctions that occur in HCC patients, and suggested SIRT-3 and HIF-1α as predictors of prognosis in early-stage HCC patients, and p-mTOR as target for the treatment of advanced-stage HCC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30917505; info:eu-repo/semantics/altIdentifier/wos/WOS:000465523400115; volume:20; issue:6; firstpage:1; lastpage:14; numberofpages:14; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11585/715157Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85063971035 |
| DOI: | 10.3390/ijms20061503 |
| الإتاحة: | https://doi.org/10.3390/ijms20061503Test http://hdl.handle.net/11585/715157Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.486D4E47 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms20061503 |
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