مراجعة
MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate.
| العنوان: | MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate. |
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| المؤلفون: | Iwaya, Chihiro, Suzuki, Akiko, Iwata, Junichi |
| المصدر: | Int J Mol Sci ; ISSN:1422-0067 ; Volume:24 ; Issue:4 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | cleft lip, cleft palate, craniofacial development, environmental factor, microRNA |
| الوصف: | Cleft lip and palate is one of the most common congenital birth defects and has a complex etiology. Either genetic or environmental factors, or both, are involved at various degrees, and the type and severity of clefts vary. One of the longstanding questions is how environmental factors lead to craniofacial developmental anomalies. Recent studies highlight non-coding RNAs as potential epigenetic regulators in cleft lip and palate. In this review, we will discuss microRNAs, a type of small non-coding RNAs that can simultaneously regulate expression of many downstream target genes, as a causative mechanism of cleft lip and palate in humans and mice. |
| نوع الوثيقة: | review article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/ijms24043552Test; https://pubmed.ncbi.nlm.nih.gov/36834963Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958963Test/ |
| DOI: | 10.3390/ijms24043552 |
| الإتاحة: | https://doi.org/10.3390/ijms24043552Test https://pubmed.ncbi.nlm.nih.gov/36834963Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958963Test/ |
| رقم الانضمام: | edsbas.485DFD84 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24043552 |
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