دورية أكاديمية
Kidney Diseases Associated With Inflammatory Bowel Disease: Impact of Chronic Histologic Damage, Treatments, and Outcomes
| العنوان: | Kidney Diseases Associated With Inflammatory Bowel Disease: Impact of Chronic Histologic Damage, Treatments, and Outcomes |
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| المؤلفون: | Yandian, Federico, Caravaca-Fontán, Fernando, Herrera Hernandez, Loren P., Sethi, Sanjeev, Fervenza, Fernando, Soler, María José |
| المساهمون: | Institut Català de la Salut, Yandian F Department of Nephrology, Hospital de Clínicas “Dr. Manuel Quintela”, Montevideo, Uruguay. Caravaca-Fontán F Department of Nephrology, Instituto de Investigación Hospital “12 de Octubre” (imas12), Madrid, Spain. Herrera Hernandez LP, Sethi S Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Soler MJ Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Fervenza FC Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Ronyons - Biòpsia, Ronyons - Malalties, Intestins - Inflamació, DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases, DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy, ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales, ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia |
| الوصف: | Inflammatory bowel disease; Interstitial nephritis; Kidney failure ; Enfermedad inflamatoria intestinal; Nefritis intersticial; Insuficiencia renal ; Malaltia inflamatòria intestinal; Nefritis intersticial; Insuficiència renal ; Introduction Kidney disease is a well-known extraintestinal manifestation (EIM) associated with inflammatory bowel disease (IBD), with a variety of underlying etiologies. However, little is known about the overall outcomes and predictors. Methods This is a retrospective, observational cohort study. Patients with IBD in whom a native kidney biopsy was performed at Mayo Clinic (Rochester, MN) between 1994 and 2022, were included. Demographic, clinical, and histologic characteristics of prognostic interest were collected. The main outcomes were kidney failure, disease remission, kidney function changes at last follow-up, and death. Results From a total cohort of 318 patients, we selected a study group of 111 patients followed-up with at our institution (45 ulcerative colitis [UC] and 66 Crohn’s disease [CD]), with a mean age of 48 ± 17 years (40% females). IgA nephropathy (IgAN), chronic interstitial nephritis (CIN), and acute interstitial nephritis (AIN) were the most common diagnoses (22%, 19%, 13%, respectively). Median estimated glomerular filtration rate (eGFR) at presentation was 30 ml/min per 1.73 m2 (interquartile range [IQR]: 17–54) and urinary protein-to-creatinine ratio [UPCR] 0.8 g/g (0.3–3.4), without differences between IBD types. During a median follow-up of 59 months (12–109), 29 patients (26%) reached kidney failure. By multivariable analysis, the main predictors of kidney failure were age (hazard ratio [HR]: 1.04; P = 0.002), baseline eGFR (HR: 0.94; P = 0.003) and histologic chronicity score (HR: 4.01; P < 0.001). Therapeutic management varied according to underlying etiology. Global survival (kidney failure + death) was significantly better in patients who achieved complete or partial remission, or stabilization or improvement of kidney function. Conclusion One-fourth ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2468-0249 38344742 |
| العلاقة: | Kidney International Reports;9(2); https://doi.org/10.1016/j.ekir.2023.11.011Test; Yandian F, Caravaca-Fontán F, Herrera Hernandez LP, Soler MJ, Sethi S, Fervenza FC. Kidney Diseases Associated With Inflammatory Bowel Disease: Impact of Chronic Histologic Damage, Treatments, and Outcomes. Kidney Int Rep. 2024 Feb;9(2):383–94.; https://hdl.handle.net/11351/11050Test |
| DOI: | 10.1016/j.ekir.2023.11.011 |
| الإتاحة: | https://doi.org/10.1016/j.ekir.2023.11.011Test https://hdl.handle.net/11351/11050Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.481B4479 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 24680249 38344742 |
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| DOI: | 10.1016/j.ekir.2023.11.011 |