رسالة جامعية
Compatibility of Polymorphism Decryption in Biomphalaria glabrata and Schistosoma mansoni interaction : an integrative approach ; Décryptage du Polymorphisme de Compatibilité dans l’interaction entre Biomphalaria glabrata et Schistosoma mansoni : une approche intégrative
| العنوان: | Compatibility of Polymorphism Decryption in Biomphalaria glabrata and Schistosoma mansoni interaction : an integrative approach ; Décryptage du Polymorphisme de Compatibilité dans l’interaction entre Biomphalaria glabrata et Schistosoma mansoni : une approche intégrative |
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| المؤلفون: | Portet, Anaïs |
| المساهمون: | Interactions Hôtes-Pathogènes-Environnements (IHPE), Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université de Perpignan, Benjamin Gourbal, Richard Galinier |
| المصدر: | https://theses.hal.science/tel-01968022Test ; Sciences agricoles. Université de Perpignan, 2017. Français. ⟨NNT : 2017PERP0035⟩. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2017 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | B. glabrata, S. manson, Innate Immunity, Local Adaptation, BgTEP, Tripartite interaction, Microbiota, S. mansoni, Immunité inné, Adaptation locale, Interaction tripartite, Microbiote, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences |
| الوصف: | Biomphalaria glabrata is tropical fresh water snail, living in Latin America. This planorbe is the intermediary host of Schistosoma mansoni, a trematode responsible for the intestinal Schistosomiasis, second worldwide human vector-borne disease after the malaria. In this context, a better comprehension of the parasite/snail interaction is necessary and appearsa promising research field. The understanding of immunological interaction between the host and the parasite and the molecular mechanisms used by the two partners appears like essential for the discovery of new targets and new strategies in order to develop means of struggle against the pathogen. The aim of this thesis is to better understand the immunological interactions between the B. glabrata snail and S. mansoni trematode. Different aspects of the interaction between the snail and the parasite have been explored, from molecular and cellular bases to the tripartite interaction between the snail immunity, its microbiota and the pathogen. In a first step we have been able to demonstrate a gradient of parasite infectivities and snail susceptibilities from different geographical origins. Moreover, the immunological interaction between B. glabrata and S. mansoni is supported by local adaptation, at the molecular level. We were also able to show than an opsonin, the BgTEP, plays a key role in the interaction between B. glabrata and its various pathogens. Finally, the existence of a true tripartite interaction between the snail immune response, its microbiota and its parasite could was demonstrated. ; Biomphalaria glabrata est un mollusque d’eau douce, vivant en Amérique latine. Ce planorbe est principalement connu pour être l’hôte intermédiaire de Schistosoma mansoni, vers plat parasite responsable de la bilharziose intestinale, seconde endémie parasitaire humaine mondiale derrière le paludisme.Dans ce contexte, il apparaît clairement qu’une meilleure compréhension de l’interaction entre le parasite et le mollusque, hôte intermédiaire, représente une voie de ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | French |
| العلاقة: | NNT: 2017PERP0035; tel-01968022; https://theses.hal.science/tel-01968022Test; https://theses.hal.science/tel-01968022/documentTest; https://theses.hal.science/tel-01968022/file/These_PORTET_ANAIS_2017a.pdfTest |
| الإتاحة: | https://theses.hal.science/tel-01968022Test https://theses.hal.science/tel-01968022/documentTest https://theses.hal.science/tel-01968022/file/These_PORTET_ANAIS_2017a.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.47EE3FBA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |