التفاصيل البيبلوغرافية
| العنوان: |
Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis |
| المؤلفون: |
van Herwijnen, M.J.C., Wieten, L., van der Zee, R., van Kooten, P.J., Wagenaar, J.P.A., Hoek, A., den Braber, A.J., Anderton, S.M., Singh, M., Meiring, H.D., van Els, C.A.C.M., van Eden, W., Broere, F. |
| المساهمون: |
Risk Assessment of Toxic and Immunomodulatory Agents, Strategic Infection Biology, Dep Infectieziekten Immunologie |
| سنة النشر: |
2012 |
| مصطلحات موضوعية: |
International (not English) |
| الوصف: |
Reestablishing self-tolerance in autoimmunity is thought to depend on self-reactive regulatory T cells (Tregs). Exploiting these antigen-specific regulators is hampered by the obscure nature of disease-relevant autoantigens. We have uncovered potent disease-suppressive Tregs recognizing Heat Shock Protein (Hsp) 70 self-antigens, enabling selective activity in inflamed tissues. Hsp70 is a major contributor to the MHC class II ligandome. Here we show that a conserved Hsp70 epitope (B29) is present in murine MHC class II and that upon transfer, B29-induced CD4+CD25+Foxp3+ T cells suppress established proteoglycan-induced arthritis in mice. These self-antigen–specific Tregs were activated in vivo, and when using Lymphocyte Activation Gene-3 as a selection marker, as few as 4,000 cells sufficed. Furthermore, depletion of transferred Tregs abrogated disease suppression. Transferred cells exhibited a stable phenotype and were found in joints and draining lymph nodes up to 2 mo after transfer. Given that (i) B29 administration by itself suppressed disease, (ii) our findings were made with wild-type (T-cell receptor nontransgenic) Tregs, and (iii) the B29 human homolog is presented by HLA class II, we are nearing translation of antigen-specific Treg activation as a promising intervention for chronic inflammatory diseases. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0027-8424 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/274552Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/274552Test |
| حقوق: |
info:eu-repo/semantics/ClosedAccess |
| رقم الانضمام: |
edsbas.47E093BA |
| قاعدة البيانات: |
BASE |
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