دورية أكاديمية
Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia
| العنوان: | Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia |
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| المؤلفون: | Guirao, B, Meunier, A, Mortaud, S, Aguilar, A, Corsi, JM, Strehl, L, Hirota, Y, Desoeuvre, A, Boutin, Camille, Han, YG, Mirzadeh, Z, Cremer, H, Montcouquiol, M, Sawamoto, K, Spassky, N |
| المساهمون: | UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire |
| المصدر: | Nature Cell Biology, Vol. 12, no.4, p. 341-50 (12 avril 2010) |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2010 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| الوصف: | In mammals, motile cilia cover many organs, such as fallopian tubes, respiratory tracts and brain ventricles. The development and function of these organs critically depend on efficient directional fluid flow ensured by the alignment of ciliary beating. To identify the mechanisms involved in this process, we analysed motile cilia of mouse brain ventricles, using biophysical and molecular approaches. Our results highlight an original orientation mechanism for ependymal cilia whereby basal bodies first dock apically with random orientations, and then reorient in a common direction through a coupling between hydrodynamic forces and the planar cell polarity (PCP) protein Vangl2, within a limited time-frame. This identifies a direct link between external hydrodynamic cues and intracellular PCP signalling. Our findings extend known PCP mechanisms by integrating hydrodynamic forces as long-range polarity signals, argue for a possible sensory role of ependymal cilia, and will be of interest for the study of fluid flow-mediated morphogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1465-7392 1476-4679 |
| العلاقة: | boreal:126494; http://hdl.handle.net/2078.1/126494Test; urn:ISSN:1465-7392; urn:EISSN:1476-4679 |
| DOI: | 10.1038/ncb2040 |
| الإتاحة: | https://doi.org/10.1038/ncb2040Test http://hdl.handle.net/2078.1/126494Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.47A5C380 |
| قاعدة البيانات: | BASE |
| تدمد: | 14657392 14764679 |
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| DOI: | 10.1038/ncb2040 |