التفاصيل البيبلوغرافية
| العنوان: |
Predictive value of pentagastrin test for preoperative differential diagnosis between C-cell hyperplasia and medullary thyroid carcinoma in patients with moderately elevated basal calcitonin levels. |
| المؤلفون: |
MILONE, FRANCESCO, LOMBARDI, GAETANO, COLAO, ANNAMARIA, FAGGIANO, ANTONGIULIO, Ramundo V., Chiofalo M. G., Severino R., Paciolla I., Pezzullo L. |
| المساهمون: |
Milone, Francesco, Ramundo, V., Chiofalo, M. G., Severino, R., Paciolla, I., Pezzullo, L., Lombardi, Gaetano, Colao, Annamaria, Faggiano, Antongiulio |
| سنة النشر: |
2010 |
| المجموعة: |
IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: |
pentagastrin test, C-cell hyperplasia, medullary thyroid cancer |
| الوصف: |
BACKGROUND AND OBJECTIVES: Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-secreting neuroendocrine tumour originating from thyroid C cells. Serum CT concentrations are helpful in the early detection of MTC, while it is still unclear whether they can be used also for the differential diagnosis between MTC and C-cell hyperplasia (CCH), a precancerous condition in familial MTCs but with unclear clinical significance in sporadic MTCs. Nowadays, surgery is recommended in all patients with basal or pentagastrin (PG)-stimulated CT value of 100 pg/ml or more, without discriminating if they are affected with MTC or CCH only. The objective of this study was to investigate the utility of the PG test for CT in distinguishing CCH from MTC before surgery. PATIENTS AND METHODS: Sixteen of 20 patients with thyroid nodules and basal CT levels between 15 and 100 ng/l had a positive PG test (>100 ng/l PG CT peak) and form the basis of the data analysis. A diagnosis of MTC was histologically proved on surgical samples in seven patients and of CCH in nine other patients. Four patients with neither FNAB nor PG test consistent with a diagnosis of MTC did not undergo thyroidectomy. RESULTS: A peak of CT of 275 ng/l after PG was able to significantly distinguish patients with MTC from patients with CCH, with 100% sensitivity and 89% specificity (P = 0.002). PG-stimulated calcitonin levels >275 ng/l had a positive predictive value (PPV) value for diagnosis of MTC of 100%, and PG-stimulated calcitonin levels <275 had a PPV for the diagnosis of CCH of 89%. CONCLUSIONS: A CT cut-off after PG of 275 ng/l is suggested to be highly predictive in distinguishing CCH from MTC before surgery, and this may be helpful in selecting patients for thyroid surgery. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/20039894; info:eu-repo/semantics/altIdentifier/wos/WOS:000278917100013; volume:73; issue:1; firstpage:85; lastpage:88; numberofpages:4; journal:CLINICAL ENDOCRINOLOGY; http://hdl.handle.net/11588/378181Test |
| الإتاحة: |
http://hdl.handle.net/11588/378181Test |
| رقم الانضمام: |
edsbas.47943868 |
| قاعدة البيانات: |
BASE |
