دورية أكاديمية
Endocrine Disruptor-Induced Bone Damage Due to Hormone Dysregulation: A Review.
| العنوان: | Endocrine Disruptor-Induced Bone Damage Due to Hormone Dysregulation: A Review. |
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| المؤلفون: | Iwobi, Nneamaka, Sparks, Nicole R |
| المصدر: | International journal of molecular sciences, vol 24, iss 9 |
| بيانات النشر: | eScholarship, University of California |
| سنة النشر: | 2023 |
| المجموعة: | University of California: eScholarship |
| مصطلحات موضوعية: | Endocrine System, Hormones, Endocrinology, Signal Transduction, Endocrine Disruptors, bone defects, endocrine toxicity, endocrine-disrupting chemicals, osteoblasts, osteogenesis, Estrogen, Genetics, 2.1 Biological and endogenous factors, Aetiology, Other Chemical Sciences, Other Biological Sciences, Chemical Physics |
| الوقت: | 8263 |
| الوصف: | Hormones are indispensable for bone development, growth, and maintenance. While many of the genes associated with osteogenesis are well established, it is the recent findings in endocrinology that are advancing the fields of bone biology and toxicology. Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. Here, we report recent discoveries describing key hormone pathways involved in osteogenesis and the EDCs that alter these pathways. EDCs can lead to bone morphological changes via altering hormone receptors, signaling pathways, and gene expression. The objective of this review is to highlight the recent discoveries of the harmful effects of environmental toxicants on bone formation and the pathways impacted. Understanding the mechanisms of how EDCs interfere with bone formation contributes to providing a comprehensive toxicological profile of a chemical. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | qt9584n12n; https://escholarship.org/uc/item/9584n12nTest; https://escholarship.org/content/qt9584n12n/qt9584n12n.pdfTest |
| DOI: | 10.3390/ijms24098263 |
| الإتاحة: | https://doi.org/10.3390/ijms24098263Test https://escholarship.org/uc/item/9584n12nTest https://escholarship.org/content/qt9584n12n/qt9584n12n.pdfTest |
| حقوق: | public |
| رقم الانضمام: | edsbas.478D287F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24098263 |
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