دورية أكاديمية
Protein kinase B/AKT isoform 2 drives migration of human mesenchymal stem cells
| العنوان: | Protein kinase B/AKT isoform 2 drives migration of human mesenchymal stem cells |
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| المؤلفون: | Bulj, Z, Duchi, S, Bevilacqua, A, Gherardi, A, Dozza, B, Piccinini, F, Mariani, GA, Lucarelli, E, Giannini, S, Donati, D, Marmiroli, S |
| بيانات النشر: | SPANDIDOS PUBL LTD |
| سنة النشر: | 2013 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | This study was designed to investigate the migratory behavior of adult human mesenchymal stem cells (MSC) and the underlying mechanism. Cell migration was assessed by transwell, wound healing and time-lapse in vivo motility assays. Pharmacological inhibitors were used to determine the potential mechanism responsible for cell migration and invasion. The tests that were implemented revealed that MSC were fairly migratory. Protein kinase B (AKT) was strongly activated at the basal level. Through our analyses we demonstrated that pharmacological inactivation of AKT2 but not AKT1 significantly decreased cell migration and invasion. Although preliminary, collectively our results indicate that AKT2 activation plays a critical role in enabling MSC migration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1019-6439 1791-2423 |
| العلاقة: | Bulj, Z., Duchi, S., Bevilacqua, A., Gherardi, A., Dozza, B., Piccinini, F., Mariani, G. A., Lucarelli, E., Giannini, S., Donati, D. & Marmiroli, S. (2013). Protein kinase B/AKT isoform 2 drives migration of human mesenchymal stem cells. INTERNATIONAL JOURNAL OF ONCOLOGY, 42 (1), pp.118-126. https://doi.org/10.3892/ijo.2012.1700Test.; http://hdl.handle.net/11343/256536Test |
| الإتاحة: | https://doi.org/10.3892/ijo.2012.1700Test http://hdl.handle.net/11343/256536Test |
| حقوق: | CC BY ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.476EE3F8 |
| قاعدة البيانات: | BASE |
| تدمد: | 10196439 17912423 |
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