رسالة جامعية
Improving the study and characterization of the impact of dietary fibers on the gut microbiota composition and functions as well as on the cardiometabolic profile in the context of nutritional intervention studies ; Améliorer l’étude et la caractérisation de l’impact des fibres alimentaires sur la composition et les fonctions du microbiote intestinal ainsi que sur le profil cardiométabolique dans le cadre d’études d’intervention nutritionnelle
| العنوان: | Improving the study and characterization of the impact of dietary fibers on the gut microbiota composition and functions as well as on the cardiometabolic profile in the context of nutritional intervention studies ; Améliorer l’étude et la caractérisation de l’impact des fibres alimentaires sur la composition et les fonctions du microbiote intestinal ainsi que sur le profil cardiométabolique dans le cadre d’études d’intervention nutritionnelle |
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| المؤلفون: | Ranaivo, Harimalala |
| المساهمون: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Claude Bernard - Lyon I, Julie-Anne Nazare, Chantal Simon |
| المصدر: | https://theses.hal.science/tel-04224021Test ; Médecine humaine et pathologie. Université Claude Bernard - Lyon I, 2022. Français. ⟨NNT : 2022LYO10027⟩. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2022 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Dietary fibers, Gut microbiota, Cardiometabolic profile, Biomarkers, Phenotypic flexibility, Posptrandial metabolism, Fermentation profile, Fibres alimentaires, Microbiote intestinal, Profil cardiométabolique, Biomarqueurs, Flexibilité phénotypique, Métabolisme postprandial, Profil de fermentation, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Cardiometabolic diseases (cardiovascular diseases, diabetes) are among the leading causes of death in the world and unfortunately their prevalence continues to increase, making their prevention a major issue for society. Risk factors associated with these cardiometabolic diseases have been identified and recently, the involvement of the gut microbiota in the development of these factors has also been reported. The development of nutritional tools with bioactive compounds such as dietary fiber may be a good way to prevent the development of cardiometabolic diseases by favorably impacting the cardiometabolic profile via modulation of the gut microbiota. However, although the beneficial effects of dietary fiber on the cardiometabolic profile are now well recognized, all the mechanisms underlying these effects are still not all clarified, particularly those that would involve modulation of the composition and functions of the microbiota. The aim of my thesis work was therefore to improve the understanding of the interaction between dietary fiber, microbiota and cardiometabolic profile. This work was based on 3 clinical studies of nutritional interventions with dietary fiber, two of which aimed to improve the cardiometabolic profile via modulation of the gut microbiota and the third one aiming at following the metabolic fate of a 13C-labelled fiber once ingested in healthy subjects by assessing fermentation metabolites. We have shown that the study and characterization of the impact of dietary fiber on the cardiometabolic profile and the gut microbiota can be improved by methodological and biomarkers’ choices adapted to the design of the study. The comprehensive phenotyping (metabolic, metagenomic, metabolomic) performed in the context of these studies also allowed for a more detailed assessment of the interaction between the cardiometabolic profile and the gut microbiota. Interestingly, we also identified that the fermentation profile, assessed by gas excretion could be a relevant biomarker to distinguish specific ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | French |
| العلاقة: | NNT: 2022LYO10027; tel-04224021; https://theses.hal.science/tel-04224021Test; https://theses.hal.science/tel-04224021/documentTest; https://theses.hal.science/tel-04224021/file/TH2022RANAIVOHARIMALALA.pdfTest |
| الإتاحة: | https://theses.hal.science/tel-04224021Test https://theses.hal.science/tel-04224021/documentTest https://theses.hal.science/tel-04224021/file/TH2022RANAIVOHARIMALALA.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.4738F8BA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |