دورية أكاديمية
Autoimmune hemolytic anemia during pregnancy and puerperium:an international multicenter experience
| العنوان: | Autoimmune hemolytic anemia during pregnancy and puerperium:an international multicenter experience |
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| المؤلفون: | Fattizzo, Bruno, Bortolotti, Marta, Fantini, Norma N., Glenthøj, Andreas, Michel, Marc, Napolitano, Mariasanta, Raso, Simona, Chen, Frederick, McDonald, Vickie, Murakhovskaya, Irina, Vos, Josephine Mathilde Iris, Patriarca, Andrea, Mingot-Castellano, Maria Eva, Giordano, Giulio, Scarrone, Margherita, González-López, Tomás José, Trespidi, Laura, Prati, Daniele, Barcellini, Wilma |
| المصدر: | Fattizzo , B , Bortolotti , M , Fantini , N N , Glenthøj , A , Michel , M , Napolitano , M , Raso , S , Chen , F , McDonald , V , Murakhovskaya , I , Vos , J M I , Patriarca , A , Mingot-Castellano , M E , Giordano , G , Scarrone , M , González-López , T J , Trespidi , L , Prati , D & Barcellini , W 2023 , ' Autoimmune hemolytic anemia during pregnancy and puerperium : an international multicenter experience ' , Blood , .... |
| سنة النشر: | 2023 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| الوصف: | Relapsing or occurring de novo autoimmune hemolytic anemia (AIHA) during pregnancy or puerperium is a poorly described condition. Here, we report 45 pregnancies in 33 women evaluated at 12 centers from 1997 to 2022. Among the 20 women diagnosed with AIHA before pregnancy, 10 had a relapse. An additional 13 patients developed de novo AIHA during gestation/puerperium (2 patients had AIHA relapse during a second pregnancy). Among 24 hemolytic events, anemia was uniformly severe (median Hb, 6.4 g/dL; range, 3.1-8.7) and required treatment in all cases (96% steroids ± intravenous immunoglobulin, IVIG, 58% transfusions). Response was achieved in all patients and was complete in 65% of the cases. Antithrombotic prophylaxis was administered to 8 patients (33%). After delivery, rituximab was administered to 4 patients, and cyclosporine was added to 1 patient. The rate of maternal complications, including premature rupture of membranes, placental detachment, and preeclampsia, was 15%. Early miscarriages occurred in 13% of the pregnancies. Fetal adverse events (22% of cases) included respiratory distress, fetal growth restriction, preterm birth, AIHA of the newborn, and 2 perinatal deaths. In conclusion, the occurrence of AIHA does not preclude the ability to carry out a healthy pregnancy, provided close monitoring, prompt therapy, and awareness of potential maternal and fetal complications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1182/blood.2022018890 |
| الإتاحة: | https://doi.org/10.1182/blood.2022018890Test https://curis.ku.dk/portal/da/publications/autoimmune-hemolytic-anemia-during-pregnancy-and-puerperiumTest(fc26fde2-2554-4487-b97b-c3c8d0d4fe75).html https://curis.ku.dk/ws/files/371656303/blood_bld_2022_018890_main.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4736BACB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood.2022018890 |
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