دورية أكاديمية
Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density
| العنوان: | Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density |
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| المؤلفون: | Kroll, Sara L, Hulka, Lea M, Kexel, Ann-Kathrin, Vonmoos, Matthias, Preller, Katrin H, Treyer, Valerie, Ametamey, Simon M, Baumgartner, Markus R, Boost, Carola, Pahlisch, Franziska, Rohleder, Cathrin, Leweke, F Markus, Quednow, Boris B |
| المصدر: | Kroll, Sara L; Hulka, Lea M; Kexel, Ann-Kathrin; Vonmoos, Matthias; Preller, Katrin H; Treyer, Valerie; Ametamey, Simon M; Baumgartner, Markus R; Boost, Carola; Pahlisch, Franziska; Rohleder, Cathrin; Leweke, F Markus; Quednow, Boris B (2023). Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. Translational Psychiatry, 13(1):325. |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2023 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Clinic for Nuclear Medicine, Clinic for Psychiatry, Psychotherapy, and Psychosomatics, 610 Medicine & health |
| الوصف: | Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders. Preclinical findings showed endocannabinoid-modulated synaptic plasticity in reward brain networks linked to the metabotropic-glutamate-5 receptor (mGluR5), contributing to drug-reinforcing effects and drug-seeking behavior. Although animal models postulate a link between ECS and cocaine addiction, human translational studies are lacking. Here, we tested previous preclinical findings by investigating plasma endocannabinoids (eCBs) anandamide (AEA), 2-arachidonoylglycerol (2-AG), and the related N-acylethanolamines (NAEs) palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), including their interaction with cerebral mGluR5, in chronic cocaine users (CU). We compared basal plasma concentrations between chronic CU (N = 103; 69 recreational CU and 34 dependent CU) and stimulant-naïve healthy controls (N = 92). Follow-up basal eCB/NAE plasma levels after 12 months were used for reliability and stability check (CU: N = 33; controls: N = 43). In an additional analysis using $^{11}$C-ABP688 positron emission tomography (PET) in a male subsample (CU: N = 18; controls: N = 16), we investigated the relationships between eCBs/NAEs and mGluR5 density in the brain. We found higher 2-AG plasma levels in dependent CU compared to controls and recreational CU. 2-AG levels were stable over time across all groups. In the PET-subsample, a positive association between 2-AG and mGluR5 brain density only in CU was found. Our results corroborate animal findings suggesting an alteration of the ECS in cocaine dependence and an association between peripheral 2-AG levels and cerebral mGluR5 in humans. Therefore, the ECS might be a promising pharmaco-therapeutic target for novel treatments of cocaine dependence. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2158-3188 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/238085/1/ZORA238085.pdfTest; info:pmid/37857616; urn:issn:2158-3188 |
| DOI: | 10.5167/uzh-238085 |
| DOI: | 10.1038/s41398-023-02628-7 |
| الإتاحة: | https://doi.org/10.5167/uzh-23808510.1038/s41398-023-02628-7Test https://www.zora.uzh.ch/id/eprint/238085Test/ https://www.zora.uzh.ch/id/eprint/238085/1/ZORA238085.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.46EAEA02 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21583188 |
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| DOI: | 10.5167/uzh-238085 |