التفاصيل البيبلوغرافية
| العنوان: |
ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas |
| المؤلفون: |
Lucie Darmusey, Gaëlle Pérot, Noémie Thébault, Sophie Le Guellec, Nelly Desplat, Laëtitia Gaston, Lucile Delespaul, Tom Lesluyes, Elodie Darbo, Anne Gomez-Brouchet, Elodie Richard, Jessica Baud, Laura Leroy, Jean-Michel Coindre, Jean-Yves Blay, Frédéric Chibon |
| المصدر: |
Cancers; Volume 13; Issue 9; Pages: 2151 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
sarcomas, ATRX, oncogenesis, mast cells, alteration |
| الوصف: |
Whole genome and transcriptome sequencing of a cohort of 67 leiomyosarcomas has been revealed ATRX to be one of the most frequently mutated genes in leiomyosarcomas after TP53 and RB1. While its function is well described in the alternative lengthening of telomeres mechanism, we wondered whether its alteration could have complementary effects on sarcoma oncogenesis. ATRX alteration is associated with the down-expression of genes linked to differentiation in leiomyosarcomas, and to immunity in an additional cohort of 60 poorly differentiated pleomorphic sarcomas. In vitro and in vivo models showed that ATRX down-expression increases tumor growth rate and immune escape by decreasing the immunity load of active mast cells in sarcoma tumors. These data indicate that an alternative to unsuccessful targeting of the adaptive immune system in sarcoma could target the innate system. This might lead to a better outcome for sarcoma patients in terms of ATRX status. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Cancer Biology; https://dx.doi.org/10.3390/cancers13092151Test |
| DOI: |
10.3390/cancers13092151 |
| الإتاحة: |
https://doi.org/10.3390/cancers13092151Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.46C5A3CE |
| قاعدة البيانات: |
BASE |
