دورية أكاديمية
Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes
| العنوان: | Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes |
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| المؤلفون: | Nigar Sekercioglu, Leif Erik Lovblom, Petter Bjornstad, Julie A. Lovshin, Yuliya Lytvyn, Geneviève Boulet, Mohammed A. Farooqi, Andrej Orszag, Vesta Lai, Josephine Tse, Leslie Cham, Hillary A. Keenan, Michael H. Brent, Narinder Paul, Vera Bril, Bruce A. Perkins, David Z. I. Cherney |
| المصدر: | Renal Failure, Vol 41, Iss 1, Pp 427-433 (2019) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | type 1 diabetes, diabetic kidney disease, diabetic neuropathy, diabetic retinopathy, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Objectives: Diabetic kidney disease (DKD) is an independent predictor of cardiovascular morbidity and mortality in type 1 diabetes (T1D). We aimed to explore clinical and biochemical factors, including the achievement of American Diabetes Association (ADA) recommended targets associated with DKD in people living with T1D for ≥50 years. Methods: This was a post hoc analysis of a cross-sectional study of 75 participants enrolled in the Canadian Study of Longevity in T1D. We explored diabetes-related complications, including neuropathy, retinopathy, cardiovascular disease, and DKD. Study participants were dichotomized based on the achievement of ADA recommended targets as the low-target group (achieving ≤4 targets, n = 31) and high-target group (achieving >4 targets, n = 44). The outcome of interest was DKD defined by estimated glomerular filtration rate (eGFR) values <60/mL/min/1.73 m2 and/or 24-h albumin excretion >30 mg. Multivariable logistic regression models were employed to estimate odds ratios (ORs) for DKD with 95% confidence intervals (CIs). Results: Of the 75 participants with prolonged T1D duration (45% male, mean age 66 years), 25 participants had DKD and 50 did not. There was no statistical difference between the high- and low-target groups in terms of age and body mass index. eGFR was significantly higher and the prevalence of diabetic retinopathy was significantly lower in the high-target group. Older age at diagnosis of T1D and lower frequency component to high-frequency component ratio increased the odds of having DKD. Conclusions: In adults with prolonged T1D duration, older age at diagnosis and lower heart rate variability may be associated with DKD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0886-022X 1525-6049 |
| العلاقة: | http://dx.doi.org/10.1080/0886022X.2019.1614057Test; https://doaj.org/toc/0886-022XTest; https://doaj.org/toc/1525-6049Test; https://doaj.org/article/e5474eaf563e403b8c103cc886b356e5Test |
| DOI: | 10.1080/0886022X.2019.1614057 |
| الإتاحة: | https://doi.org/10.1080/0886022X.2019.1614057Test https://doaj.org/article/e5474eaf563e403b8c103cc886b356e5Test |
| رقم الانضمام: | edsbas.469F430 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0886022X 15256049 |
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| DOI: | 10.1080/0886022X.2019.1614057 |