دورية أكاديمية
Minimal model SG overestimation and SI underestimation : improved accuracy by a Bayesian two-compartment model
| العنوان: | Minimal model SG overestimation and SI underestimation : improved accuracy by a Bayesian two-compartment model |
|---|---|
| المؤلفون: | C. Cobelli, M. Omenetto, A. Caumo |
| المساهمون: | C. Cobelli, A. Caumo, M. Omenetto |
| بيانات النشر: | American Physiological Society |
| سنة النشر: | 1999 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Glucose clamp technique, Glucose effectivene, Glucose kinetic, Insulin sensitivity, Settore ING-INF/06 - Bioingegneria Elettronica e Informatica |
| الوصف: | The intravenous glucose tolerance test (IVGTT) single-compartment minimal model (1CMM) method has recently been shown to overestimate glucose effectiveness and underestimate insulin sensitivity. Undermodeling, i.e., use of single- instead of two-compartment description of glucose kinetics, has been advocated to explain these limitations. We describe a new two-compartment minimal model (2CMM) into which we incorporate certain available knowledge on glucose kinetics. 2CMM is numerically identified using a Bayesian approach. Twenty-two standard IVGTT (0.30 g/kg) in normal humans were analyzed. In six subjects, the clamp-based index of insulin sensitivity (ScI) was also measured. 2CMM glucose effectiveness (S2G) and insulin sensitivity (S2I) were, respectively, 60% lower (P < 0.0001) and 35% higher (P < 0.0001) than the corresponding 1CMM S1G and S1I indexes: 2.81 +/- 0.29 (SE) vs. S1G = 4.27 +/- 0.33 ml. min(-1). kg(-1) and S2I = 11.67 +/- 1.71 vs. S1I = 8.68 +/- 1.62 10(2) ml. min(-1). kg(-1) per microU/ml. S2I was not different from ScI = 12.61 +/- 2.13 10(2) ml. min(-1). kg(-1) per microU/ml (nonsignificant), whereas S1I was 60% lower (P < 0.02). In conclusion, a new 2CMM has been presented that improves the accuracy of glucose effectiveness and insulin sensitivity estimates of the classic 1CMM from a standard IVGTT in normal humans. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/10484360; volume:277; issue:3; firstpage:E481; lastpage:E488; journal:AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/2434/162381Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033194665; http://ajpendo.physiology.org/content/277/3/E481.full.pdf+htmlTest |
| الإتاحة: | http://hdl.handle.net/2434/162381Test http://ajpendo.physiology.org/content/277/3/E481.full.pdf+htmlTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.463F4F35 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |