دورية أكاديمية
Coacervates of whey proteins to protect and improve the oral delivery of a bioactive molecule
| العنوان: | Coacervates of whey proteins to protect and improve the oral delivery of a bioactive molecule |
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| المؤلفون: | Chapeau, Anne Laure, Bertrand, Nicolas, Briard-Bion, Valérie, Hamon, Pascaline, Poncelet, Denis, Bouhallab, Said |
| المساهمون: | Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Laboratoire de génie des procédés - environnement - agroalimentaire (GEPEA), Institut Universitaire de Technologie - Nantes (IUT Nantes), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut Universitaire de Technologie Saint-Nazaire (IUT Saint-Nazaire), Université de Nantes (UN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Institut Universitaire de Technologie - La Roche-sur-Yon (IUT La Roche-sur-Yon), Université de Nantes (UN), Faculty of Pharmacy, CHU de Quebec Research Center, Université Laval Québec (ULaval), Institute of Nutrition and Functional Foods INAF, Regional councils of Brittany (grant n 13008651) and Pays de la Loire (grant n 2014-07081) and INRA, France for the financial support of this work through the interregional project PROFIL, supported by BBA industrial association and managed by the ‘‘Pôle Agronomique Ouest”. Additional funding from the Natural Sciences and Engineering Research Council of Canada (Discovery Grant to N. B.) |
| المصدر: | ISSN: 1756-4646. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | protection, formulation, drug kinetics, vitamine b9, molécule bioactive, coacervation, encapsulation, pharmacocinétique, bioaccessibilité, formulation alimentaire, matrice alimentaire, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.IDA]Life Sciences [q-bio]/Food engineering |
| الوصف: | The potentiality of heteroprotein complex coacervates as biocarrier for a bioactive was investigated.Vitamin B9 (B9), also known as folic acid, was encapsulated by complex coacervation of two whey proteins(WP), b-lactoglobulin and lactoferrin. The stability and bioavailability of formed B9-WP coacervateswas then characterized. Under degradative conditions in vitro (UV light irradiation, and oxidation byH2O2), WP coacervates protected the vitamin against chemical degradation. B9-WP coacervates alsoshowed considerable physical stability over time when incorporated in real food matrices. Comparedto unencapsulated B9, oral administration of B9-WP coacervates to healthy rats enhanced the plasmalevel of the vitamin. This improved bioavailability can be ascribed to the improvement in the solubilityof B9 throughout the gastro-intestinal tract. We thus demonstrate the efficiency of WP coacervates asbiocarrier for the protection and delivery of small bioactive molecules. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01593201; https://hal.science/hal-01593201Test; https://hal.science/hal-01593201/documentTest; https://hal.science/hal-01593201/file/ALC_JFF_2017_%7BB33A7091-A159-48D5-83E3-5A117834388A%7D.pdfTest; PRODINRA: 408659; WOS: 000414890500019 |
| DOI: | 10.1016/j.jff.2017.09.009 |
| الإتاحة: | https://doi.org/10.1016/j.jff.2017.09.009Test https://hal.science/hal-01593201Test https://hal.science/hal-01593201/documentTest https://hal.science/hal-01593201/file/ALC_JFF_2017_%7BB33A7091-A159-48D5-83E3-5A117834388A%7D.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.4625F6A2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jff.2017.09.009 |
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