التفاصيل البيبلوغرافية
| العنوان: |
Characterization and Relative Efficacy of Muscarinic Receptor Antagonism at the Hypoglossal Motor Nucleus to Block Inhibition of Tongue Motor Activity |
| المؤلفون: |
Niakani, Sepehr |
| المساهمون: |
Horner, Richard L, Physiology |
| بيانات النشر: |
University of Toronto |
| سنة النشر: |
2021 |
| المجموعة: |
University of Toronto: Research Repository T-Space |
| مصطلحات موضوعية: |
Genioglossus, Hypoglossal, Muscarinic receptor, Obstructive sleep apnea, omadacycline, oxybutynin |
| الوقت: |
0719 |
| الوصف: |
The hypoglossal motor nucleus (HMN) is the origin of motor output to the tongue, with decreased activity in sleep precipitating obstructive sleep apnea (OSA) in humans. Our laboratory has identified that muscarinic receptor antagonism at the HMN increases tongue motor activity in sleep. A clinical study also showed that oxybutynin (a muscarinic receptor antagonist) combined with atomoxetine (a noradrenaline reuptake inhibitor) greatly reduced OSA severity; however, their site of action is unknown. Accordingly, we hypothesized that oxybutynin is an effective muscarinic receptor antagonist at the HMN, and characterized its relative efficacy with other muscarinic receptor antagonists. We recorded tongue muscle activity of anesthetized rats in response to the microperfusion of HMN with several muscarinic receptor antagonists during (i) muscarinic receptor stimulation and (ii) increased endogenous acetylcholine elicited by eserine. This thesis identifies that oxybutynin prevents tongue motor suppression due to increased endogenous acetylcholine by antagonizing muscarinic receptors at the HMN. ; M.Sc. |
| نوع الوثيقة: |
thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
http://hdl.handle.net/1807/108983Test |
| الإتاحة: |
http://hdl.handle.net/1807/108983Test |
| حقوق: |
Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.4619D0E8 |
| قاعدة البيانات: |
BASE |
