التفاصيل البيبلوغرافية
| العنوان: |
Table_1_Characterization of Nucleocytoplasmic Shuttling of Pseudorabies Virus Protein UL46.DOCX |
| المؤلفون: |
Jing-jing Xu, Fei Gao, Ji-qiang Wu, Hao Zheng, Wu Tong, Xue-fei Cheng, Yuting Liu, Haojie Zhu, Xinling Fu, Yifeng Jiang, Liwei Li, Ning Kong, Guoxin Li, Guangzhi Tong |
| سنة النشر: |
2020 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Animal Systematics and Taxonomy, Animal Physiology - Biophysics, Animal Physiology - Cell, Animal Physiology - Systems, Animal Behaviour, Animal Cell and Molecular Biology, Animal Developmental and Reproductive Biology, Animal Immunology, Animal Neurobiology, Animal Physiological Ecology, Animal Structure and Function, Veterinary Anaesthesiology and Intensive Care, Veterinary Anatomy and Physiology, Veterinary Diagnosis and Diagnostics, Veterinary Epidemiology, Veterinary Immunology, Veterinary Medicine, Veterinary Microbiology (excl. Virology), Veterinary Parasitology, Veterinary Pathology, Veterinary Pharmacology, Veterinary Surgery, Veterinary Virology, Veterinary Sciences not elsewhere classified, pseudorabies virus, VP11/12, nucleocytoplasmic shuttling, nuclear localization signal, VP16, EP0 |
| الوصف: |
Pseudorabies virus (PRV) is the etiological agent of Aujeszky's disease, which has caused severe economic loss in China since its re-emergence in 2011. UL46, a late gene of herpesvirus, codes for the abundant but non-essential viral phosphoproteins 11 and 12 (VP11/12). In this study, VP11/12 was found to localize inside both the nucleus and cytoplasm. The nuclear localization signal (NLS) of VP11/12 was identified as 3 RRARGTRRASWKDASR 18 . Further research identified α5 and α7 to be the receptors for NLS and the chromosome region maintenance 1 (CRM1) to be the receptor for the nuclear export signal. Moreover, we found that PRV VP11/12 interacts with EP0 and the stimulator of interferon genes protein (STING), whereas the NLS of VP11/12 is the important part for VP11/12 to interact with UL48. To our knowledge, this is the first study to provide reliable evidence verifying the nuclear localization of VP11/12 and its role as an additional shuttling tegument protein for PRV. In addition, this is also the first study to elucidate the interactions between PRV VP11/12 and EP0 as well as between PRV VP11/12 and STING, while identifying the precise interaction sites of PRV VP11/12 and VP16. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_1_Characterization_of_Nucleocytoplasmic_Shuttling_of_Pseudorabies_Virus_Protein_UL46_DOCX/12840128Test |
| DOI: |
10.3389/fvets.2020.00484.s001 |
| الإتاحة: |
https://doi.org/10.3389/fvets.2020.00484.s001Test
https://figshare.com/articles/dataset/Table_1_Characterization_of_Nucleocytoplasmic_Shuttling_of_Pseudorabies_Virus_Protein_UL46_DOCX/12840128Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.45D9A897 |
| قاعدة البيانات: |
BASE |
