دورية أكاديمية
Outcomes of COVID-19 Hospitalized Patients Previously Treated with Renin-Angiotensin System Inhibitors
| العنوان: | Outcomes of COVID-19 Hospitalized Patients Previously Treated with Renin-Angiotensin System Inhibitors |
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| المؤلفون: | Cordeanu, Eléna-Mihaela, Jambert, Lucas, Séverac, François, Lambach, Hélène, Tousch, Jonathan, Heitz, Marie, Mirea, Corina, Hamade, Amer, Younes, Waël, Frantz, Anne-Sophie, Merdji, Hamid, Schini-Kerth, Valérie, Bilbault, Pascal, Meziani, Ferhat, Ohlmann, Patrick, Andres, Emmanuel, Stephan, Dominique |
| المساهمون: | Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Centre Hospitalier Emile Muller Mulhouse (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), CH Colmar, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://hal.science/hal-03606629Test ; Journal of Clinical Medicine, 2020, 9 (11), ⟨10.3390/jcm9113472⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, angiotensin II receptor blocker, angiotensin-converting enzyme, propensity score, renin–angiotensin system inhibitor, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] |
| الوصف: | Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) penetrates respiratory epithelium through angiotensin-converting enzyme-2 binding, raising concerns about the potentially harmful effects of renin-angiotensin system inhibitors (RASi) on Human Coronavirus Disease 2019 (COVID-19) evolution. This study aimed to provide insight into the impact of RASi on SARS-CoV-2 outcomes in patients hospitalized for COVID-19. Methods: This was a retrospective analysis of hospitalized adult patients with SARS-CoV-2 infection admitted to a university hospital in France. The observation period ended at hospital discharge. Results: During the study period, 943 COVID-19 patients were admitted to our institution, of whom 772 were included in this analysis. Among them, 431 (55.8%) had previously known hypertension. The median age was 68 (56-79) years. Overall, 220 (28.5%) patients were placed under mechanical ventilation and 173 (22.4%) died. According to previous exposure to RASi, we defined two groups, namely, "RASi" (n = 282) and "RASi-free" (n = 490). Severe pneumonia (defined as leading to death and/or requiring intubation, high-flow nasal oxygen, noninvasive ventilation, and/or oxygen flow at a rate of >= 5 L/min) and death occurred more frequently in RASi-treated patients (64% versus 53% and 29% versus 19%, respectively). However, in a propensity score-matched cohort derived from the overall population, neither death (hazard ratio (HR) 0.93 (95% confidence interval (CI) 0.57-1.50), p = 0.76) nor severe pneumonia (HR 1.03 (95%CI 0.73-1.44), p = 0.85) were associated with RASi therapy. Conclusion: Our study showed no correlation between previous RASi treatment and death or severe COVID-19 pneumonia after adjustment for confounders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33126565; hal-03606629; https://hal.science/hal-03606629Test; https://hal.science/hal-03606629/documentTest; https://hal.science/hal-03606629/file/jcm-09-03472.pdfTest; PUBMED: 33126565; PUBMEDCENTRAL: PMC7692895 |
| DOI: | 10.3390/jcm9113472 |
| الإتاحة: | https://doi.org/10.3390/jcm9113472Test https://hal.science/hal-03606629Test https://hal.science/hal-03606629/documentTest https://hal.science/hal-03606629/file/jcm-09-03472.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.458DADC6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jcm9113472 |
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