دورية أكاديمية
Phenotypic and functional analysis of γδ T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection
| العنوان: | Phenotypic and functional analysis of γδ T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection |
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| المؤلفون: | Ruggieri, Matias, Ducasa, Nicolas, Juraske, Claudia, Polo, Virginia Gonzalez, Berini, Carolina, Quiroga, Maria Florencia, Christopoulos, Petros, Minguet, Susana, Biglione, Mirna, Schamel, Wolfgang |
| المصدر: | Frontiers in immunology. - 13 (2022) , 920888, ISSN: 1664-3224 |
| سنة النشر: | 2022 |
| المجموعة: | University of Freiburg: FreiDok |
| الوصف: | The human T-cell leukemia virus type 1 (HTLV-1) is the cause of serious malignant and inflammatory diseases, including adult T-cell leukemia and lymphoma and tropical spastic paraparesis. The potential protective role of γδ T cells in HTLV-1 infection remains unclear. Here, demonstrate that there is a decrease in the amount of Vγ9Vδ2 T cells in patients with HTLV-1, especially in those with HTLV-1 associated pathologies. This suggests that γδ T cells could be involved in controlling the virus. Indeed, we found that Vγ9Vδ2 T cells, expanded from non-infected individuals, can kill cells expressing the viral proteins HBZ and Tax and this phenotype is reversed in the presence of mevastatin. Cytotoxicity by Vγ9Vδ2 T cells was not associated with an increase of INF-γ production. In sharp contrast, killing by NK cells was reduced by Tax expression. Thus, our study provides initial evidence for a potential protective role of Vγ9Vδ2 T cells against HTLV-1 infection. Therapeutic exploitation of these insights is feasible with current technologies of T-cell therapies and could provide novel tools to prevent and treat HTLV-1-associated malignancies and neurologic complications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | https://freidok.uni-freiburg.de/data/229127Test |
| DOI: | 10.3389/fimmu.2022.920888 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2022.920888Test https://freidok.uni-freiburg.de/data/229127Test https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2291272Test https://freidok.uni-freiburg.de/dnb/download/229127Test |
| حقوق: | free |
| رقم الانضمام: | edsbas.4587D71B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2022.920888 |
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